What's on this Page
Acquired purpura fulminans
- A life-threatening, rapidly progressive thrombotic disorder affecting mainly neonates and children that is characterized by purpuric skin lesions and disseminated intravascular coagulation. It may progress rapidly to multi-organ failure caused by thrombotic occlusion of small and medium-sized blood vessels.
- There are two forms of the disorder that are classified according to triggering mechanisms: acute infectious (the most common form), and idiopathic purpura fulminans.
Age of onset:
- Adult
- Childhood
- Infancy
- Neonatal
What are the symptoms of Acquired purpura fulminans?
Most frequent (common) symptoms
- Abnormal blistering of the skin
- Abnormal thrombosis
- Acrocyanosis
- Decreased erythrocyte sedimentation rate
- Disseminated intravascular coagulation
- Elevated circulating C-reactive protein concentration
- Erythematous macule
- Gangrene
- Hypofibrinogenemia
- Immune dysregulation
- Macular purpura
- Macule
- Prolonged partial thromboplastin time
- Prolonged prothrombin time
- Reduced protein C activity
- Reduced protein S activity
- Shock
- Skin rash
- Thrombocytopenia
Occasional symptoms
- Hepatic failure
- Internal hemorrhage
- Intracranial hemorrhage
- Neoplasm
- Sepsis
Very rare symptoms
- Pyoderma gangrenosum