Acquired purpura fulminans

Acquired purpura fulminans

  • A life-threatening, rapidly progressive thrombotic disorder affecting mainly neonates and children that is characterized by purpuric skin lesions and disseminated intravascular coagulation. It may progress rapidly to multi-organ failure caused by thrombotic occlusion of small and medium-sized blood vessels.
  • There are two forms of the disorder that are classified according to triggering mechanisms: acute infectious (the most common form), and idiopathic purpura fulminans.

Age of onset: 

  • Adult
  • Childhood
  • Infancy
  • Neonatal

What are the symptoms of Acquired purpura fulminans?

Most frequent (common) symptoms

  • Abnormal blistering of the skin
  • Abnormal thrombosis
  • Acrocyanosis
  • Decreased erythrocyte sedimentation rate
  • Disseminated intravascular coagulation
  • Elevated circulating C-reactive protein concentration
  • Erythematous macule
  • Gangrene
  • Hypofibrinogenemia
  • Immune dysregulation
  • Macular purpura
  • Macule
  • Prolonged partial thromboplastin time
  • Prolonged prothrombin time
  • Reduced protein C activity
  • Reduced protein S activity
  • Shock
  • Skin rash
  • Thrombocytopenia

Occasional symptoms

  • Hepatic failure
  • Internal hemorrhage
  • Intracranial hemorrhage
  • Neoplasm
  • Sepsis

Very rare symptoms

  • Pyoderma gangrenosum
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