How is Sepsis associated acute kidney injury treated
What is the treatment of AKI resulting from sepsis?
Currently, there are no specific therapies for either prevention or treatment of septic acute kidney injury.
However, it is critically important that appropriate and timely supportive care be delivered. This includes the following:
a. Rapid fluid resuscitation to ensure adequate blood pressure and organ perfusion
b. Appropriate use of vasopressors to ensure adequate blood pressure and organ perfusion
c. Timely administration of antimicrobials
d. Avoidance of nephrotoxic exposures, such as intravenous contrast or nonsteroidal anti-inflammatory drugs
e. Timely initiation of dialysis in patients with oliguria, positive fluid balance, and signs of irreversible kidney injury or with metabolic derangements (hyperkalemia and metabolic acidosis) that cannot be treated with non-dialysis therapies. The exact timing for the initiation of dialysis remains controversial.
Novel therapies that target specific pathogenic pathways are being actively studied in animal models and offer promise for future human use.