How common is Cardiorenal syndrome type 3
What’s the epidemiology of Cardiorenal syndrome type 3?
Acute Kidney Injury may occur in 70% of ICU patients.
From 5% to 25% of ICU patients develop severe Acute Kidney Injury with mortality rates ranging from 50% to 80%.
ADHF, defined as new-onset, gradual or rapid worsening of preexisting HF with signs and symptoms requiring immediate therapy, represents the most common etiology of acute cardiac dysfunction syndrome.
Cardiac valvular disease, atrial fibrillation, arterial hypertension as well as noncardiac comorbidities (kidney dysfunction, diabetes, anemia) and medications (especially nonsteroidal anti-inflammatory drugs and glitazones) can contribute to ADHF development.
According to the Acute Decompensated Heart Failure National Registry database, kidney dysfunction increases mortality in ADHF patients from 1.9% in those with mild kidney disease to 7.6% in those with severe kidney dysfunction.
Other adverse prognostic factors are a low EF, low systolic blood pressure, hyponatremia, older age, and elevated C-reactive protein (CRP) levels.
Acute Kidney Injury leads to heart dysfunction, which then decreases perfusion of the kidney, which further compromises cardiac function in a self-perpetuating cycle of cardiac and kidney failure.
