• A rare inborn error of metabolism characterized by a deficiency in erythrocyte catalase, an enzyme responsible for the breakdown of hydrogen peroxide.
  • The disorder is usually asymptomatic but may be associated with oral ulcerations and gangrene, or diabetes mellitus and atherosclerosis in certain populations.


Catalase deficiency


How common is Acatalasemia?

1-9 /100000


Autosomal recessive 

Age of Onset

All ages

What are the symptoms of Acatalasemia?

Very Common Symptoms

Reduced catalase activity

Common Symptoms

Oral ulcer

Occasional Symptoms

  • Gangrene 
  • Gingival bleeding 
  • Gingivitis
  • Microcytic anemia
  • Old-aged sensorineural hearing impairment
  • Severe periodontitis
  • Type II diabetes mellitus

Rare Symptoms

  • Arteriosclerosis
  • Neoplasm of the larynx
  • Pain
  • Parkinsonism 
  • Premature loss of permanent teeth
  • Schizophrenia
  • Type I diabetes mellitus
  • Vitiligo

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