Disease of the exocrine pancreas (e.g., pancreatectomy, pancreatitis) can result in the development of diabetes. What are the characteristics of this type of diabetes?
Both beta and alpha cells are affected, resulting in both insulin and glucagon deficiency. These patients require insulin and are at greater risk for hypoglycemia as a result of glucagon deficiency. Glucagon is also essential for the formation of ketone bodies. Without insulin, these patients develop hyperglycemia but are less likely to develop ketosis (i.e., diabetic ketoacidosis).