How is type 1 diabetes treated

therapeutic options available for the treatment of type 1 diabetes

Patients with type 1 diabetes have deficiency of both insulin and amylin. Without insulin these patients develop hyperglycemia and ketosis (i.e., diabetic ketoacidosis). These patients typically require long-acting insulin (glargine, detemir, neutral protamine Hagedorn [NPH]) to cover basal needs and short acting insulin (i.e., lispro, aspart, glulisine, regular) to cover meals. Insulin can also be delivered via a pump devise in select patients. The predominant side effect is hypoglycemia. 

Amylin analogues (i.e., pramlintide) can also be prescribed in type 1 diabetes to suppress glucagon mediated hepatic glucose production, improve satiety, and slow gastric emptying. Amylin injections are given in addition to insulin. Modest weight loss and improvements in hemoglobin A1c (< 1%) are noted with treatment. Risk of hypoglycemia and the inconvenience of multiple daily injections limit the use of amylin.


Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

Scroll to Top