Endocrine Syndromes Associated with Acromegaly

Are other endocrine syndromes possible in patients with acromegaly or gigantism?

Yes. Otherwise acromegaly and gigantism would not be endocrine disorders. Three endocrine syndromes include acromegaly

Endocrine Syndromes Associated with Acromegaly

SYNDROMEMAJOR INVOLVED ORGANSCLINICAL FINDINGSOTHER CLUES
Multiple endocrine neoplasia type 1 (MEN 1)Pituitary tumors
Parathyroid hyperplasia
Islet cell tumors
Hypercalcemia (most)
Peptic ulcer disease (if gastrinoma)
Hypoglycemia (if insulinoma)
Autosomal dominant
Check calcium levels in patients with acromegaly
McCune-Albright syndromeBones
Skin
Gonads
Others
Polyostotic fibrous dysplasia
Café-au-lait spots
Sexual precocity
Mostly in girls
Carney’s complexHeart
Skin
Adrenals
Others
Cardiac myomas
Pigmented skin lesions
Pigmented nodular adrenal hyperplasiaMany other tumorsAutosomal dominant
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