Endocrine Syndromes Associated with Acromegaly

Are other endocrine syndromes possible in patients with acromegaly or gigantism?

  • Yes. Otherwise acromegaly and gigantism would not be endocrine disorders. Three endocrine syndromes include acromegaly

Endocrine Syndromes Associated with Acromegaly

SYNDROMEMAJOR INVOLVED ORGANSCLINICAL FINDINGSOTHER CLUES
Multiple endocrine neoplasia type 1 (MEN 1)Pituitary tumors
Parathyroid hyperplasia
Islet cell tumors
Hypercalcemia (most)
Peptic ulcer disease (if gastrinoma)
Hypoglycemia (if insulinoma)
Autosomal dominant
Check calcium levels in patients with acromegaly
McCune-Albright syndromeBones
Skin
Gonads
Others
Polyostotic fibrous dysplasia
Café-au-lait spots
Sexual precocity
Mostly in girls
Carney’s complexHeart
Skin
Adrenals
Others
Cardiac myomas
Pigmented skin lesions
Pigmented nodular adrenal hyperplasiaMany other tumorsAutosomal dominant
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