Are some Growth hormone producing tumors more aggressive than others

Are some Growth hormone producing tumors more aggressive than others, and is there a way to tell?

GH-producing tumors causing acromegaly are often characterized histologically as being densely granulated or sparsely granulated. Sparsely granulated GH-producing tumors are less well-differentiated tumors, are generally more locally aggressive, respond less well to somatostatin analogues, and have a worse prognosis.

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