What is the conservative treatment for Membranous Nephropathy?
Conservative therapy for Membranous Nephropathy consists of low sodium diet (<2.3 grams/day), lowering lipids and controlling blood pressure (target blood pressure ≤125/75 mm Hg).
Inhibition of the renin-angiotensin-aldosterone system (RAAS) with angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) are effective antihypertensive agents that can reduce proteinuria and slow progression of kidney disease in patients with nephropathy with or without diabetes, and for these reasons they are the preferred agents to treat hypertension in MN.
However, the antiproteinuric effect of ACE inhibitors or ARB is modest (<30% decrease) and is more significant in patients with lower levels of proteinuria.
