Symptoms of Membranous Nephropathy
What are the clinical manifestations of MN?
At presentation, 60% to 70% of patients have nephrotic syndrome, with the remaining 30% to 40% of patients presenting with proteinuria <3.5 g/24 hours in an otherwise asymptomatic patient.
Although more than 90% of patients have no evidence of impaired kidney function at the time of presentation, hypertension at onset is found in 10% to 20% of patients.
The presence of microscopic hematuria is common (30% to 40%), but macroscopic hematuria and red cells casts are rare and these findings should suggest an alternative diagnosis.
Findings of physical examination may vary from mild peripheral edema to full-blown nephrotic syndrome, including ascites and pericardial and pleural effusions.
