Common amyloidoses in the elderly

Common amyloidoses in the elderly

Other than systemic AL amyloidosis, there are two amyloidoses that occur more commonly in the elderly

• Age-related (senile) amyloidosis: deposits of normal transthyretin amyloid (ATTR) are common in patients aged over 70 years. Males are more commonly affected. The most commonly involved organ is the heart, and patients can present with a restrictive cardiomyopathy. Some patients have CTS. Other organs are rarely involved clinically.

• Aβ protein amyloidosis: deposits of β-protein in Alzheimer’s plaques. It can also be deposited in cerebral blood vessels (cerebral amyloid angiopathy) leading to strokes and hemorrhage, which can mimic central nervous system vasculitis.

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