What is localized AL amyloidosis and how does it present?
Amyloid may occur in localized deposits, resembling tumors. The lung, skin, larynx, eye, and bladder are common sites. The deposits are attributable to a focal infiltrate of monoclonal B cells that produce amyloidogenic light chains. If the amyloid deposits are interfering with organ function or causing bleeding, surgical or laser excision can be done. Progression of this form of localized amyloid to systemic disease or to myeloma is exceedingly rare.