What the best method to estimate kidney function for drug dosing in CKD?
Most approved drugs advice to use CG method by the way to estimated kidney function for medication dosage adjustment in patients with kidney disease.
Recently, it has been questioned that other methods of estimating kidney function perhaps are more accurate than CG method for estimating kidney function. It is important to remember that CG formula, MDRD, and Chronic Kidney Disease-Epidemiology (CKD-EPI) Collaboration equation are only an “estimation” and “approximation” of kidney function.
Neither of these methods provides accurate “measurement” or “calculation” of kidney function. In addition, there are many other changes in the kidney that might affect drug handling than just filtration rate such tubular function and organic acid accumulations.
Health care providers should also consider drug safety and efficacy for dosage adjustment. In general, a number of recent studies comparing the equations for their influence on drug dosage adjustment have shown that the MDRD perhaps is a better method with a greater concordance with measured GFR compared with other methods.
