Will Acute Kidney Injury indirectly decrease heart function?
As kidney function declines, it can result in significant pathophysiological derangement, leading to cardiac injury.
Acute Kidney Injury can lead to fluid overload causing hypertension, pulmonary edema, and myocardial injury.
Electrolyte imbalances, primarily hyperkalemia, can cause arrhythmias and sudden death.
Acidemia can worsen pulmonary vasoconstriction, increased right ventricular afterload, and contribute to a negative inotropic effect.
Uremia itself can directly decrease myocardial contractility and promote pericardial effusions and pericarditis.
In response to systemic and kidney hemodynamic changements, baroceptor and intrarenal chemoceptors lead to SNS and RAAS activation.