Alleviation of Arthritic Symptoms in IBD

Can treatment alleviate the symptoms of inflammatory peripheral arthritis or spinal arthritis in IBD patients?

Alleviation of Arthritic Symptoms in Inflammatory Bowel Disease

Peripheral ArthritisSacroiliitis/Spondylitis
NSAIDs *YesYes
Intra-articular corticosteroidsYesYes (sacroiliitis)
SulfasalazineYesNo
Immunosuppressives (MTX, 6-MP)YesNo
Anti-TNFαYesYes
Bowel resection
UCYesNo
CDNoNo

CD, Crohn’s disease; FDA, Food and Drug Administration; IBD, inflammatory bowel disease; 6-MP, 6-mercaptopurine; MTX, methotrexate; NSAID, nonsteroidal antiinflammatory drug; TNF, tumor necrosis factor; UC, ulcerative colitis.

* NSAIDs may exacerbate IBD. Sulfasalazine helps the peripheral arthritis in UC patients more than CD patients. Anti-TNFα agents that are FDA-approved and effective include infliximab, adalimumab, golimumab, and certolizumab pegol.

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