Can treatment alleviate the symptoms of inflammatory peripheral arthritis or spinal arthritis in IBD patients?
Alleviation of Arthritic Symptoms in Inflammatory Bowel Disease
| Peripheral Arthritis | Sacroiliitis/Spondylitis | |
|---|---|---|
| NSAIDs * | Yes | Yes |
| Intra-articular corticosteroids | Yes | Yes (sacroiliitis) |
| Sulfasalazine | Yes | No |
| Immunosuppressives (MTX, 6-MP) | Yes | No |
| Anti-TNFα | Yes | Yes |
| Bowel resection | ||
| UC | Yes | No |
| CD | No | No |
CD, Crohn’s disease; FDA, Food and Drug Administration; IBD, inflammatory bowel disease; 6-MP, 6-mercaptopurine; MTX, methotrexate; NSAID, nonsteroidal antiinflammatory drug; TNF, tumor necrosis factor; UC, ulcerative colitis.
* NSAIDs may exacerbate IBD. Sulfasalazine helps the peripheral arthritis in UC patients more than CD patients. Anti-TNFα agents that are FDA-approved and effective include infliximab, adalimumab, golimumab, and certolizumab pegol.
