Vemurafenib

What is Vemurafenib

Vemurafenib is a serine/threonine-protein kinase BRAF inhibitor. Vemurafenib is indicated for the treatment of melanoma in patients with V600E mutations of the BRAF gene; it is not indicated for use in patients with wild-type BRAF.

Vemurafenib is also indicated for the treatment of Erdheim-Chester disease in patients with BRAF V600E mutations.

Secondary malignancies including new primary cutaneous malignancies and noncutaneous squamous cell carcinoma have been reported; monitor patients closely for signs or symptoms of new malignancies.

Brand Name

Zelboraf

Indications

  • colorectal cancer
  • Erdheim-Chester disease
  • hairy-cell leukemia
  • malignant melanoma

Side Effects

  1. alopecia
  2. alopecia
  3. anaphylactoid reactions
  4. anorexia
  5. arthralgia
  6. arthralgia
  7. asthenia
  8. asthenia
  9. atrial fibrillation
  10. back pain
  11. back pain
  12. blurred vision
  13. coagulopathy
  14. constipation
  15. constipation
  16. cough
  17. cranial nerve palsies
  18. diarrhea
  19. diarrhea
  20. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  21. Dupuytren’s contracture
  22. dysgeusia
  23. elevated hepatic enzymes
  24. elevated hepatic enzymes
  25. eosinophilia
  26. erythema
  27. erythema nodosum
  28. fatigue
  29. fatigue
  30. fever
  31. fever
  32. folliculitis
  33. headache
  34. headache
  35. hyperbilirubinemia
  36. hyperkeratosis
  37. hyperkeratosis
  38. hypertension
  39. hypertension
  40. hypotension
  41. interstitial nephritis
  42. iritis
  43. lymphadenopathy
  44. maculopapular rash
  45. maculopapular rash
  46. musculoskeletal pain
  47. myalgia
  48. myalgia
  49. myocarditis
  50. nausea
  51. nausea
  52. nephrotoxicity
  53. neutropenia
  54. new primary malignancy
  55. palmar-plantar erythrodysesthesia (hand and foot syndrome)
  56. pancreatitis
  57. panniculitis
  58. peripheral edema
  59. peripheral edema
  60. peripheral neuropathy
  61. photophobia
  62. photosensitivity
  63. photosensitivity
  64. plantar fibromatosis
  65. pleural effusion
  66. pruritus
  67. pruritus
  68. QT prolongation
  69. QT prolongation
  70. radiation recall reaction
  71. rash
  72. rash
  73. renal failure (unspecified)
  74. renal tubular necrosis
  75. retinal thrombosis
  76. skin cancer
  77. Stevens-Johnson syndrome
  78. toxic epidermal necrolysis
  79. uveitis
  80. vasculitis
  81. vomiting
  82. vomiting
  83. xerosis

Monitoring Parameters

  • ECG
  • LFTs
  • serum bilirubin
  • serum creatinine
  • serum electrolytes
  • skin cancer screening exam

Contraindications

  • alcoholism
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • coagulopathy
  • contraception requirements
  • coronary artery disease
  • diabetes mellitus
  • Dupuytren’s contracture
  • females
  • fever
  • geriatric
  • heart failure
  • hepatic disease
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypotension
  • iritis
  • long QT syndrome
  • malnutrition
  • myocardial infarction
  • new primary malignancy
  • plantar fibromatosis
  • pregnancy
  • QT prolongation
  • radiation therapy
  • renal failure
  • reproductive risk
  • serious rash
  • sunburn
  • sunlight (UV) exposure
  • thyroid disease

Interactions

  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aclidinium; Formoterol
  • Afatinib
  • Albuterol
  • Albuterol; Ipratropium
  • Aldesleukin, IL-2
  • Alfentanil
  • Alfuzosin
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Alosetron
  • Alpelisib
  • Amiodarone
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anagrelide
  • Apalutamide
  • Apomorphine
  • Aprepitant, Fosaprepitant
  • Arformoterol
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atomoxetine
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azithromycin
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bendamustine
  • Benzhydrocodone; Acetaminophen
  • Betrixaban
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Boceprevir
  • Bortezomib
  • Bosentan
  • Brimonidine; Timolol
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Caffeine
  • Caffeine; Ergotamine
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carvedilol
  • Ceritinib
  • Cevimeline
  • Chloramphenicol
  • Chloroquine
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Cilostazol
  • Cimetidine
  • Cinacalcet
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clonazepam
  • Clozapine
  • Cobicistat
  • Cobimetinib
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Dabigatran
  • Daclatasvir
  • Danazol
  • Dapsone
  • Darifenacin
  • Darolutamide
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Degarelix
  • Delavirdine
  • Deutetrabenazine
  • Dexamethasone
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diclofenac
  • Diclofenac; Misoprostol
  • Digoxin
  • Dihydroergotamine
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Disulfiram
  • Docetaxel
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Dorzolamide; Timolol
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elbasvir; Grazoprevir
  • Eletriptan
  • Eliglustat
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Encainide
  • Encorafenib
  • Entrectinib
  • Enzalutamide
  • Eplerenone
  • Ergotamine
  • Eribulin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estazolam
  • Eszopiclone
  • Ethosuximide
  • Etodolac
  • Etravirine
  • Ezogabine
  • Famotidine; Ibuprofen
  • Felodipine
  • Fenoprofen
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Flurbiprofen
  • Flutamide
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvastatin
  • Fluvoxamine
  • Formoterol
  • Formoterol; Mometasone
  • Fosamprenavir
  • Foscarnet
  • Fosphenytoin
  • Gemifloxacin
  • Gemtuzumab Ozogamicin
  • Gilteritinib
  • Glasdegib
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycopyrrolate; Formoterol
  • Goserelin
  • Granisetron
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Haloperidol
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxychloroquine
  • Hydroxyprogesterone
  • Hydroxyzine
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Imatinib
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indinavir
  • Indomethacin
  • Inotuzumab Ozogamicin
  • Ipilimumab
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isradipine
  • Itraconazole
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lansoprazole; Naproxen
  • Lapatinib
  • Ledipasvir; Sofosbuvir
  • Lefamulin
  • Lenvatinib
  • Letermovir
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levalbuterol
  • Levofloxacin
  • Lithium
  • Lofexidine
  • Long-acting beta-agonists
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Losartan
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Lurasidone
  • Macimorelin
  • Maprotiline
  • Maraviroc
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Mefloquine
  • Meperidine; Promethazine
  • Mesoridazine
  • Metaproterenol
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Methadone
  • Metoprolol
  • Metronidazole
  • Mexiletine
  • Midazolam
  • Midostaurin
  • Mifepristone
  • Mirtazapine
  • Mitomycin
  • Mitotane
  • Modafinil
  • Morphine
  • Morphine; Naltrexone
  • Moxifloxacin
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nateglinide
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nelfinavir
  • Nicotine
  • Nilotinib
  • Nimodipine
  • Nisoldipine
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olodaterol
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Ondansetron
  • Oritavancin
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxaprozin
  • Oxybutynin
  • Oxycodone
  • Ozanimod
  • Paclitaxel
  • Paliperidone
  • Panobinostat
  • Paricalcitol
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimavanserin
  • Pimozide
  • Pirbuterol
  • Pirfenidone
  • Piroxicam
  • Pitolisant
  • Porfimer
  • Posaconazole
  • Praziquantel
  • Prednisolone
  • Prednisone
  • Primaquine
  • Primidone
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propranolol
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Repaglinide
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Rilpivirine
  • Riluzole
  • Rimegepant
  • Risperidone
  • Ritonavir
  • Rivaroxaban
  • Rolapitant
  • Romidepsin
  • Ropinirole
  • Rosiglitazone
  • Salmeterol
  • Sapropterin
  • Saquinavir
  • Selpercatinib
  • Sertraline
  • Short-acting beta-agonists
  • Sildenafil
  • Silodosin
  • Simeprevir
  • Siponimod
  • Sirolimus
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Solifenacin
  • Sorafenib
  • Sotalol
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulindac
  • Sunitinib
  • Tacrine
  • Tacrolimus
  • Tadalafil
  • Tafamidis
  • Talazoparib
  • Tamoxifen
  • Tamsulosin
  • Tasimelteon
  • Tedizolid
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Telotristat Ethyl
  • Temsirolimus
  • Teniposide
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Terbinafine
  • Terbutaline
  • Testosterone
  • Tetrabenazine
  • Theophylline, Aminophylline
  • Thiabendazole
  • Thioridazine
  • Tiagabine
  • Ticagrelor
  • Timolol
  • Tinidazole
  • Tiotropium; Olodaterol
  • Tipranavir
  • Tizanidine
  • Tolbutamide
  • Tolmetin
  • Tolterodine
  • Tolvaptan
  • Topiramate
  • Topotecan
  • Toremifene
  • Torsemide
  • Tramadol
  • Trandolapril; Verapamil
  • Trazodone
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Triptorelin
  • Tucatinib
  • Ubrogepant
  • Umeclidinium; Vilanterol
  • Valdecoxib
  • Vandetanib
  • Vardenafil
  • Venetoclax
  • Venlafaxine
  • Verapamil
  • Verteporfin
  • Vinblastine
  • Vincristine
  • Vincristine Liposomal
  • Vorapaxar
  • Voriconazole
  • Vorinostat
  • Warfarin
  • Zafirlukast
  • Zileuton
  • Ziprasidone
  • Zolpidem
  • Zonisamide
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top