Urea (carbamide)

What is Urea (carbamide)

Urea (also known as carbamide) is available as topical formulations and a powder for oral solution. It is used topically to treat dry skin (xerosis) and for destruction and dissolution of dystrophic nails due to onychomycosis.

As an oral agent, urea is an osmotic diuretic and is used for the treatment of hyponatremia, particularly due to SIADH.

Brand Names

Aluvea | BP-50% Urea | BP-K50 | Carmol | CEM-Urea | Cerovel | Epimide-50 | Gord Urea | Gordons Urea | Hydro 35 | Hydro 40 | Kerafoam | Kerafoam 42 | Keralac | Keralac Nailstik | Keratol | Keratol Plus | Kerol | Kerol AD | Kerol ZX | Latrix | Mectalyte | Nutraplus | RE Urea 40 | RE Urea 50 | Rea Lo | Remeven | RE-U40 | RYNODERM | U40 | U-Kera | Ultra Mide 25 | Ultralytic-2 | Umecta | Umecta Nail Film | URALISS | Uramaxin | Uramaxin GT | Urea | Ureacin | Urealac | Ureaphil | Uredeb | URE-K | Uremez-40 | Ure-Na | Uresol | Utopic | Vanamide | Xurea | X-VIATE

Indications

  • hyponatremia
  • ichthyosis
  • onychomycosis
  • SIADH
  • xerosis

Side Effects

  • diarrhea
  • headache
  • hypernatremia
  • hypokalemia
  • skin irritation
  • vomiting

Monitoring Parameters

  • serum osmolality
  • serum sodium
  • urine osmolality

Contraindications

  • breast-feeding
  • pregnancy

Interactions

  • Acetazolamide
  • Aminoglycosides
  • Carbonic anhydrase inhibitors
  • Desmopressin
  • Epoprostenol
  • Iloprost
  • Inamrinone
  • Lithium
  • Methazolamide
  • Nifedipine
  • Nonsteroidal antiinflammatory drugs
  • Octreotide
  • Sotalol
  • Tolterodine
  • Triamcinolone
  • Vasopressin, ADH
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