Umeclidinium (Incruse Ellipta)

What is Umeclidinium (Incruse Ellipta)

Umeclidinium is a respiratory antimuscarinic (anticholinergic), often referred to as a long-acting muscarinic antagonist (LAMA), that is used once a day.

It is FDA-approved for the maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD).

According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, umeclidinium may be used as initial monotherapy in all groups of COPD patients; however, combination therapy with a long-acting beta-agonist (LABA) or inhaled corticosteroid (ICS) may be needed in patients in Group D or in patients still experiencing dyspnea or exacerbations upon follow-up

Brand Name

INCRUSE ELLIPTA

Indications

  • chronic bronchitis
  • chronic obstructive pulmonary disease (COPD)
  • emphysema

Side Effects

  • abdominal pain
  • anaphylactoid reactions
  • angioedema
  • arthralgia
  • atrial fibrillation
  • blurred vision
  • bronchospasm
  • conjunctivitis
  • constipation
  • cough
  • depression
  • diarrhea
  • dizziness
  • dyspepsia
  • ecchymosis
  • headache
  • infection
  • myalgia
  • nausea
  • ocular hypertension
  • pharyngitis
  • pruritus
  • rash
  • rhinitis
  • sinus tachycardia
  • supraventricular tachycardia (SVT)
  • urinary retention
  • urticaria
  • vertigo
  • wheezing
  • xerostomia

Monitoring Parameters

  • pulmonary function tests (PFTs)

Contraindications

  • acute bronchospasm
  • angioedema
  • anticholinergic medications
  • bladder obstruction
  • breast-feeding
  • children
  • closed-angle glaucoma
  • contact lenses
  • geriatric
  • infants
  • milk protein hypersensitivity
  • neonates
  • ocular exposure
  • ophthalmic administration
  • paradoxical bronchospasm
  • pregnancy
  • prostatic hypertrophy

Interactions

  • Aclidinium
  • Aclidinium; Formoterol
  • Anticholinergics
  • Brigatinib
  • Daclatasvir
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Fosamprenavir
  • Glecaprevir; Pibrentasvir
  • Isavuconazonium
  • Lumacaftor; Ivacaftor
  • Methacholine
  • Mirabegron
  • Osimertinib
  • Peginterferon Alfa-2b
  • Rolapitant
  • Sapropterin
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Sorafenib
  • Temsirolimus
  • Trandolapril; Verapamil
  • Verapamil
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