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What is Triprolidine
Triprolidine is a first generation oral sedating antihistamine (H1-blocker) belonging to the alkylamine class.
It is used for the treatment of allergic and vasomotor rhinitis, allergic conjunctivitis, and uncomplicated skin manifestations of angioedema and urticaria. Triprolidine was approved by the FDA in 1958.
Indications & Dosage
- allergic conjunctivitis
- allergic rhinitis
- rhinorrhea
- sneezing
For the treatment of symptoms associated with perennial and seasonal allergic rhinitis or other respiratory allergies, including rhinorrhea, sneezing, itching of the nose or throat, or allergic conjunctivitis
Side Effects
- agitation
- anorexia
- anxiety
- arrhythmia exacerbation
- blurred vision
- confusion
- constipation
- dizziness
- drowsiness
- dyskinesia
- dysuria
- hallucinations
- headache
- impotence (erectile dysfunction)
- insomnia
- irritability
- lethargy
- mydriasis
- nausea
- orthostatic hypotension
- peripheral vasodilation
- polyuria
- pyrosis (heartburn)
- seizures
- sinus tachycardia
- skin irritation
- urinary retention
- vomiting
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- anticholinergic medications
- asthma
- bladder obstruction
- breast-feeding
- bronchitis
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- contact lenses
- driving or operating machinery
- emphysema
- geriatric
- GI obstruction
- hepatic disease
- hypertension
- hyperthyroidism
- infants
- neonates
- peptic ulcer disease
- phenylketonuria
- pregnancy
- prostatic hypertrophy
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Alfentanil
- Alosetron
- Amantadine
- Ambenonium Chloride
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Anticholinergics
- Apomorphine
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Barbiturates
- Belladonna; Opium
- Benzodiazepines
- Benzphetamine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butorphanol
- Cannabidiol
- Capsaicin; Metaxalone
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carisoprodol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorzoxazone
- Clobazam
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclobenzaprine
- Dantrolene
- Daratumumab; Hyaluronidase
- Desloratadine
- Desloratadine; Pseudoephedrine
- Dexmedetomidine
- Dextroamphetamine
- Dextromethorphan; Promethazine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Dronabinol
- Droperidol
- Entacapone
- Eszopiclone
- Ethanol
- Etomidate
- Ezogabine
- Fentanyl
- Flibanserin
- Fluoxetine; Olanzapine
- Fluphenazine
- Fospropofol
- Gabapentin
- Galantamine
- Gilteritinib
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halogenated Anesthetics
- Haloperidol
- Heparin
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Iloperidone
- Isocarboxazid
- Ketamine
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levomethadyl
- Levorphanol
- Lithium
- Loratadine
- Loratadine; Pseudoephedrine
- Loxapine
- Lumateperone
- Lurasidone
- Magnesium Salts
- Maprotiline
- Meclizine
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Meprobamate
- Metaxalone
- Methadone
- Methamphetamine
- Methocarbamol
- Metoclopramide
- Metyrapone
- Metyrosine
- Minocycline
- Mirtazapine
- Mitotane
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nefazodone
- Olanzapine
- Opiate Agonists
- Orphenadrine
- Oxycodone
- Oxymorphone
- Paliperidone
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenylephrine; Promethazine
- Pimozide
- Pramipexole
- Pregabalin
- Procarbazine
- Prochlorperazine
- Promethazine
- Propofol
- Propoxyphene
- Quetiapine
- Ramelteon
- Rasagiline
- Remifentanil
- Risperidone
- Rituximab; Hyaluronidase
- Rivastigmine
- Ropinirole
- Safinamide
- Selegiline
- Sincalide
- Sodium Iodide
- Solifenacin
- Sufentanil
- Suvorexant
- Tacrine
- Tasimelteon
- Thalidomide
- Thioridazine
- Thiothixene
- Tizanidine
- Tolcapone
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Trospium
- Vigabatrin
- Vilazodone
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem
