Trazodone

What is Trazodone

Trazodone is an oral antidepressant, unrelated to tricyclic or tetracyclic antidepressants.

It possesses some similarities of action to other antidepressant drugs, however, and also has some action as an anxiolytic.

Trazodone is used in the treatment of major depression, generalized anxiety disorder, and insomnia.

Trazodone was approved by the FDA in 1981.

In February 2010, an extended-release formulation was approved for the treatment of major depression in adults.

Brand Names

  • Desyrel
  • Oleptro

Indications

  1. alcohol dependence
  2. depression
  3. generalized anxiety disorder (GAD)
  4. insomnia
  5. panic disorder

For the treatment of major depression

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. agitation
  4. akathisia
  5. alopecia
  6. amnesia
  7. anemia
  8. anorexia
  9. anxiety
  10. aphasia
  11. apnea
  12. appetite stimulation
  13. arrhythmia exacerbation
  14. ataxia
  15. atrial fibrillation
  16. back pain
  17. bladder discomfort
  18. blurred vision
  19. bradycardia
  20. breast enlargement
  21. cardiac arrest
  22. chest pain (unspecified)
  23. chills
  24. cholestasis
  25. confusion
  26. constipation
  27. depression
  28. diarrhea
  29. diplopia
  30. dizziness
  31. drowsiness
  32. dysgeusia
  33. dyspnea
  34. edema
  35. ejaculation dysfunction
  36. excitability
  37. fatigue
  38. flatulence
  39. flushing
  40. gastroesophageal reflux
  41. hallucinations
  42. headache
  43. hearing loss
  44. heart failure
  45. hematuria
  46. hemolytic anemia
  47. hirsutism
  48. hostility
  49. hyperbilirubinemia
  50. hyperhidrosis
  51. hypertension
  52. hypoesthesia
  53. hyponatremia
  54. hypotension
  55. impaired cognition
  56. impotence (erectile dysfunction)
  57. increased urinary frequency
  58. insomnia
  59. jaundice
  60. leukocytosis
  61. libido decrease
  62. libido increase
  63. malaise
  64. mania
  65. memory impairment
  66. menstrual irregularity
  67. methemoglobinemia
  68. migraine
  69. musculoskeletal pain
  70. myalgia
  71. myocardial infarction
  72. nasal congestion
  73. nausea
  74. night sweats
  75. nightmares
  76. ocular pain
  77. orgasm dysfunction
  78. orthostatic hypotension
  79. palpitations
  80. paranoia
  81. paresthesias
  82. photophobia
  83. photosensitivity
  84. premature ventricular contractions (PVCs)
  85. priapism
  86. pruritus
  87. psoriasis
  88. psychosis
  89. QT prolongation
  90. rash
  91. respiratory arrest
  92. seizures
  93. serotonin syndrome
  94. SIADH
  95. suicidal ideation
  96. syncope
  97. tardive dyskinesia
  98. tinnitus
  99. torsade de pointes
  100. tremor
  101. urinary incontinence
  102. urinary retention
  103. urinary urgency
  104. urticaria
  105. ventricular tachycardia
  106. vertigo
  107. visual impairment
  108. vomiting
  109. weakness
  110. weight gain
  111. weight loss
  112. xerophthalmia
  113. xerostomia

Monitoring Parameters

  • blood pressure
  • heart rate
  • thyroid function tests (TFTs)

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • alcoholism
  • anticoagulant therapy
  • bipolar disorder
  • bleeding
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • closed-angle glaucoma
  • coadministration with other CNS depressants
  • coronary artery disease
  • dehydration
  • diabetes mellitus
  • driving or operating machinery
  • electroconvulsive therapy (ECT)
  • ethanol ingestion
  • females
  • geriatric
  • heart failure
  • hepatic disease
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hyponatremia
  • hypotension
  • hypovolemia
  • increased intraocular pressure
  • long QT syndrome
  • malnutrition
  • mania
  • MAOI therapy
  • myocardial infarction
  • orthostatic hypotension
  • pregnancy
  • priapism
  • QT prolongation
  • renal failure
  • renal impairment
  • suicidal ideation
  • syncope
  • thrombolytic therapy
  • thyroid disease

Interactions

  • Abciximab
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acrivastine; Pseudoephedrine
  • Alfentanil
  • Alfuzosin
  • Alprazolam
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamines
  • Anagrelide
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anticoagulants
  • Apalutamide
  • Apomorphine
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atomoxetine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Azithromycin
  • Baclofen
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Beta-adrenergic blockers
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Boceprevir
  • Bosentan
  • Brexpiprazole
  • Brivaracetam
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Calcium-channel blockers
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Cenobamate
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chloramphenicol
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroquine
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Choline Salicylate; Magnesium Salicylate
  • Cilostazol
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clemastine
  • Clofazimine
  • Clomipramine
  • Clonazepam
  • Clonidine
  • Clopidogrel
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Conivaptan
  • Crizotinib
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Dantrolene
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Degarelix
  • Delavirdine
  • Desflurane
  • Desipramine
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diazoxide
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dipyridamole
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Doxazosin
  • Doxepin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Duloxetine
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elbasvir; Grazoprevir
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Encorafenib
  • Enflurane
  • Entacapone
  • Entrectinib
  • Enzalutamide
  • Eplerenone
  • Epoprostenol
  • Eptifibatide
  • Eribulin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esketamine
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Ezogabine
  • Fenoldopam
  • Fentanyl
  • Fingolimod
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fluvoxamine
  • Fosamprenavir
  • Foscarnet
  • Fosphenytoin
  • Gabapentin
  • Gemifloxacin
  • Gemtuzumab Ozogamicin
  • Gilteritinib
  • Ginkgo, Ginkgo biloba
  • Glasdegib
  • Goserelin
  • Granisetron
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanfacine
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxyzine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Iloprost
  • Imipramine
  • Indinavir
  • Inotuzumab Ozogamicin
  • Isavuconazonium
  • Isocarboxazid
  • Isoflurane
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Letermovir
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levocetirizine
  • Levofloxacin
  • Levomilnacipran
  • Levorphanol
  • Linezolid
  • Lisdexamfetamine
  • Lithium
  • Lofexidine
  • Long-acting beta-agonists
  • Loop diuretics
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorazepam
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Macimorelin
  • Magnesium Salicylate
  • Maprotiline
  • Mecamylamine
  • Meclizine
  • Mefloquine
  • Meperidine
  • Meperidine; Promethazine
  • Meprobamate
  • Mesoridazine
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methylene Blue
  • Metronidazole
  • Metyrapone
  • Midazolam
  • Midostaurin
  • Mifepristone
  • Milnacipran
  • Minoxidil
  • Mirtazapine
  • Mitotane
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Moxifloxacin
  • Nabilone
  • Nalbuphine
  • Nefazodone
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nilotinib
  • Nitroprusside
  • Nonsteroidal antiinflammatory drugs
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ondansetron
  • Oritavancin
  • Orphenadrine
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paliperidone
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenobarbital
  • Phenoxybenzamine
  • Phentolamine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimavanserin
  • Pimozide
  • Pitolisant
  • Posaconazole
  • Potassium-sparing diuretics
  • Prasugrel
  • Prazosin
  • Pregabalin
  • Primaquine
  • Primidone
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propoxyphene
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Quinidine
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Reserpine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Rilpivirine
  • Risperidone
  • Ritonavir
  • Romidepsin
  • Safinamide
  • Salicylates
  • Salsalate
  • Saquinavir
  • Secobarbital
  • Selegiline
  • Selpercatinib
  • Serotonin-Receptor Agonists
  • Sertraline
  • Sevoflurane
  • Short-acting beta-agonists
  • Sibutramine
  • Simeprevir
  • Siponimod
  • Solifenacin
  • Sorafenib
  • Sotalol
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tamoxifen
  • Tapentadol
  • Tasimelteon
  • Tedizolid
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Telotristat Ethyl
  • Temazepam
  • Terazosin
  • Tetrabenazine
  • Thalidomide
  • Thiazide diuretics
  • Thioridazine
  • Thiothixene
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Tipranavir
  • Tolcapone
  • Tolterodine
  • Toremifene
  • Tramadol
  • Tranylcypromine
  • Treprostinil
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimipramine
  • Triprolidine
  • Triptorelin
  • Tucatinib
  • Valerian, Valeriana officinalis
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilazodone
  • Voriconazole
  • Vorinostat
  • Vortioxetine
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolpidem
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top