What is Trazodone
Trazodone is an oral antidepressant, unrelated to tricyclic or tetracyclic antidepressants.
It possesses some similarities of action to other antidepressant drugs, however, and also has some action as an anxiolytic.
Trazodone is used in the treatment of major depression, generalized anxiety disorder, and insomnia.
Trazodone was approved by the FDA in 1981.
In February 2010, an extended-release formulation was approved for the treatment of major depression in adults.
Brand Names
- Desyrel
- Oleptro
Indications
- alcohol dependence
- depression
- generalized anxiety disorder (GAD)
- insomnia
- panic disorder
For the treatment of major depression
Side Effects
- abdominal pain
- acne vulgaris
- agitation
- akathisia
- alopecia
- amnesia
- anemia
- anorexia
- anxiety
- aphasia
- apnea
- appetite stimulation
- arrhythmia exacerbation
- ataxia
- atrial fibrillation
- back pain
- bladder discomfort
- blurred vision
- bradycardia
- breast enlargement
- cardiac arrest
- chest pain (unspecified)
- chills
- cholestasis
- confusion
- constipation
- depression
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysgeusia
- dyspnea
- edema
- ejaculation dysfunction
- excitability
- fatigue
- flatulence
- flushing
- gastroesophageal reflux
- hallucinations
- headache
- hearing loss
- heart failure
- hematuria
- hemolytic anemia
- hirsutism
- hostility
- hyperbilirubinemia
- hyperhidrosis
- hypertension
- hypoesthesia
- hyponatremia
- hypotension
- impaired cognition
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- jaundice
- leukocytosis
- libido decrease
- libido increase
- malaise
- mania
- memory impairment
- menstrual irregularity
- methemoglobinemia
- migraine
- musculoskeletal pain
- myalgia
- myocardial infarction
- nasal congestion
- nausea
- night sweats
- nightmares
- ocular pain
- orgasm dysfunction
- orthostatic hypotension
- palpitations
- paranoia
- paresthesias
- photophobia
- photosensitivity
- premature ventricular contractions (PVCs)
- priapism
- pruritus
- psoriasis
- psychosis
- QT prolongation
- rash
- respiratory arrest
- seizures
- serotonin syndrome
- SIADH
- suicidal ideation
- syncope
- tardive dyskinesia
- tinnitus
- torsade de pointes
- tremor
- urinary incontinence
- urinary retention
- urinary urgency
- urticaria
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- weakness
- weight gain
- weight loss
- xerophthalmia
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
- thyroid function tests (TFTs)
Contraindications
- abrupt discontinuation
- acute myocardial infarction
- alcoholism
- anticoagulant therapy
- bipolar disorder
- bleeding
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- closed-angle glaucoma
- coadministration with other CNS depressants
- coronary artery disease
- dehydration
- diabetes mellitus
- driving or operating machinery
- electroconvulsive therapy (ECT)
- ethanol ingestion
- females
- geriatric
- heart failure
- hepatic disease
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypotension
- hypovolemia
- increased intraocular pressure
- long QT syndrome
- malnutrition
- mania
- MAOI therapy
- myocardial infarction
- orthostatic hypotension
- pregnancy
- priapism
- QT prolongation
- renal failure
- renal impairment
- suicidal ideation
- syncope
- thrombolytic therapy
- thyroid disease
Interactions
- Abciximab
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acetazolamide
- Acrivastine; Pseudoephedrine
- Alfentanil
- Alfuzosin
- Alprazolam
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Anagrelide
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticoagulants
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Azithromycin
- Baclofen
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Beta-adrenergic blockers
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bosentan
- Brexpiprazole
- Brivaracetam
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Calcium-channel blockers
- Cannabidiol
- Capsaicin; Metaxalone
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloramphenicol
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroquine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Choline Salicylate; Magnesium Salicylate
- Cilostazol
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clemastine
- Clofazimine
- Clomipramine
- Clonazepam
- Clonidine
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Conivaptan
- Crizotinib
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dantrolene
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Degarelix
- Delavirdine
- Desflurane
- Desipramine
- Desvenlafaxine
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diazoxide
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dipyridamole
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxazosin
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Duloxetine
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entacapone
- Entrectinib
- Enzalutamide
- Eplerenone
- Epoprostenol
- Eptifibatide
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Estazolam
- Eszopiclone
- Ethanol
- Ezogabine
- Fenoldopam
- Fentanyl
- Fingolimod
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluvoxamine
- Fosamprenavir
- Foscarnet
- Fosphenytoin
- Gabapentin
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Ginkgo, Ginkgo biloba
- Glasdegib
- Goserelin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxychloroquine
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Ibutilide
- Idelalisib
- Iloperidone
- Iloprost
- Imipramine
- Indinavir
- Inotuzumab Ozogamicin
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lapatinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lenvatinib
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levocetirizine
- Levofloxacin
- Levomilnacipran
- Levorphanol
- Linezolid
- Lisdexamfetamine
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorazepam
- Lumacaftor; Ivacaftor
- Lumateperone
- Macimorelin
- Magnesium Salicylate
- Maprotiline
- Mecamylamine
- Meclizine
- Mefloquine
- Meperidine
- Meperidine; Promethazine
- Meprobamate
- Mesoridazine
- Metaxalone
- Methadone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methylene Blue
- Metronidazole
- Metyrapone
- Midazolam
- Midostaurin
- Mifepristone
- Milnacipran
- Minoxidil
- Mirtazapine
- Mitotane
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Nabilone
- Nalbuphine
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nilotinib
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Ondansetron
- Oritavancin
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Panobinostat
- Paroxetine
- Pasireotide
- Pazopanib
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phenoxybenzamine
- Phentolamine
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pitolisant
- Posaconazole
- Potassium-sparing diuretics
- Prasugrel
- Prazosin
- Pregabalin
- Primaquine
- Primidone
- Procainamide
- Procarbazine
- Prochlorperazine
- Promethazine
- Propafenone
- Propoxyphene
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Ramelteon
- Ranolazine
- Rasagiline
- Remifentanil
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Rilpivirine
- Risperidone
- Ritonavir
- Romidepsin
- Safinamide
- Salicylates
- Salsalate
- Saquinavir
- Secobarbital
- Selegiline
- Selpercatinib
- Serotonin-Receptor Agonists
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Sibutramine
- Simeprevir
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sunitinib
- Suvorexant
- Tacrolimus
- Tamoxifen
- Tapentadol
- Tasimelteon
- Tedizolid
- Telaprevir
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Temazepam
- Terazosin
- Tetrabenazine
- Thalidomide
- Thiazide diuretics
- Thioridazine
- Thiothixene
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tipranavir
- Tolcapone
- Tolterodine
- Toremifene
- Tramadol
- Tranylcypromine
- Treprostinil
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triprolidine
- Triptorelin
- Tucatinib
- Valerian, Valeriana officinalis
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Vilazodone
- Voriconazole
- Vorinostat
- Vortioxetine
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem
