Trastuzumab

What is Trastuzumab

Indications

• breast cancer
• gastric cancer

For the treatment of patients with HER2-positive breast cancer

Side Effects

1. abdominal pain
2. acne vulgaris
3. acute respiratory distress syndrome (ARDS)
4. anaphylactic shock
5. anaphylactoid reactions
6. anemia
7. anemia
8. angioedema
9. anorexia
10. antibody formation
11. arthralgia
12. asthenia
13. back pain
14. bone pain
15. cardiomyopathy
16. chills
17. chills
18. constipation
19. cough
20. depression
21. diarrhea
22. dizziness
23. dysgeusia
24. dyspepsia
25. dysphagia
26. dyspnea
27. edema
28. epistaxis
29. fatigue
30. fatigue
31. fever
32. fever
33. glomerulonephritis
34. headache
35. heart failure
36. hot flashes
37. hyperphosphatemia
38. hypertension
39. hyperuricemia
40. hypokalemia
41. hypokalemia
42. hypotension
43. hypoxia
44. infection
45. infection
46. influenza
47. infusion-related reactions
48. infusion-related reactions
49. insomnia
50. leukopenia
51. myalgia
52. myocardial infarction
53. nausea
54. nephrotic syndrome
55. neuritis
56. neutropenia
57. neutropenia
58. palpitations
59. paresthesias
60. peripheral edema
61. peripheral neuropathy
62. pharyngitis
63. pleural effusion
64. pneumonitis
65. pruritus
66. pulmonary edema
67. pulmonary fibrosis
68. pulmonary hypertension
69. pulmonary toxicity
70. rash
71. renal failure (unspecified)
72. rhinitis
73. sinus tachycardia
74. sinusitis
75. stomatitis
76. teratogenesis
77. thrombocytopenia
78. thrombocytopenia
79. thrombosis
80. tumor lysis syndrome (TLS)
81. vomiting
82. weight loss

Monitoring Parameters

• ejection fraction
• pregnancy testing

Contraindications

• angioedema
• asthma
• benzyl alcohol hypersensitivity
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• chemotherapy
• chronic lung disease (CLD)
• chronic obstructive pulmonary disease (COPD)
• contraception requirements
• ensure correct formulation selection
• geriatric
• heart failure
• human anti-human antibody (HAHA)
• hypertension
• hypotension
• infusion-related reactions
• neutropenia
• pneumonitis
• pregnancy
• pregnancy testing
• pulmonary disease
• pulmonary fibrosis
• pulmonary toxicity
• reproductive risk
• respiratory distress syndrome
• tumor lysis syndrome (TLS)
• ventricular dysfunction

Interactions

• Anthracyclines
• Daunorubicin
• Doxorubicin
• Epirubicin
• Idarubicin
• Palifermin
• Penicillamine
• Tuberculin Purified Protein Derivative, PPD