Tolterodine

What is Tolterodine

Tolterodine is a antimuscarinic anticholinergic agent administered orally for the treatment of patients with overactive bladder.

Tolterodine helps to reduce urinary frequency and urgency, and helps to reduce urge-related incontinence.

Tolterodine has been studied extensively in the elderly, and may be preferred in the geriatric population over other antimuscarinic drugs for overactive bladder.

Final FDA approval in the United States was granted March 25, 1998; tolterodine was the first new drug approved for this condition in over 20 years.

In Europe, the drug is sold by the trade name ‘Detrusitol’. An extended-release dosage form, Detrol® LA, was FDA approved in December 2000.

Brand Name

Detrol | Detrol LA

Indications

  • overactive bladder (OAB)
  • urinary incontinence
  • urinary urgency

For the treatment of an overactive bladder (OAB) with symptoms of urinary frequency, urinary urgency, or urge-related urinary incontinence

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. angioedema
  4. anxiety
  5. arthralgia
  6. blurred vision
  7. chest pain (unspecified)
  8. confusion
  9. constipation
  10. diarrhea
  11. dizziness
  12. drowsiness
  13. dyspepsia
  14. dysuria
  15. fatigue
  16. hallucinations
  17. headache
  18. infection
  19. influenza
  20. memory impairment
  21. palpitations
  22. peripheral edema
  23. QT prolongation
  24. sinus tachycardia
  25. sinusitis
  26. Stevens-Johnson syndrome
  27. urinary retention
  28. vertigo
  29. visual impairment
  30. weight gain
  31. xerophthalmia
  32. xerosis
  33. xerostomia

Monitoring Parameters

  • LFTs

Contraindications

  • alcoholism
  • anticholinergic medications
  • autonomic neuropathy
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • closed-angle glaucoma
  • contact lenses
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • females
  • gastroesophageal reflux disease (GERD)
  • gastroparesis
  • geriatric
  • GI obstruction
  • heart failure
  • hepatic disease
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • ileus
  • infants
  • long QT syndrome
  • malnutrition
  • myasthenia gravis
  • myocardial infarction
  • neonates
  • pregnancy
  • prostatic hypertrophy
  • pyloric stenosis
  • QT prolongation
  • renal disease
  • renal failure
  • renal impairment
  • thyroid disease
  • toxic megacolon
  • ulcerative colitis
  • urinary retention
  • urinary tract obstruction

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Alfentanil
  • Alfuzosin
  • Amantadine
  • Ambenonium Chloride
  • Amiodarone
  • Amlodipine; Celecoxib
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anagrelide
  • Anticholinergics
  • Apomorphine
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azithromycin
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Boceprevir
  • Bosentan
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Butorphanol
  • Caffeine
  • Caffeine; Ergotamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Celecoxib
  • Ceritinib
  • Chloramphenicol
  • Chlordiazepoxide; Clidinium
  • Chloroquine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
  • Crizotinib
  • Cyclobenzaprine
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Degarelix
  • Delavirdine
  • Desvenlafaxine
  • Deutetrabenazine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dicyclomine
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Dronedarone
  • Droperidol
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elbasvir; Grazoprevir
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Encorafenib
  • Entrectinib
  • Eribulin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Ezogabine
  • Fentanyl
  • Fingolimod
  • Flavoxate
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fluvoxamine
  • Fosamprenavir
  • Foscarnet
  • Galantamine
  • Gallium Ga 68 Dotatate
  • Gemifloxacin
  • Gemtuzumab Ozogamicin
  • Gilteritinib
  • Givosiran
  • Glasdegib
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Glycopyrronium
  • Goserelin
  • Granisetron
  • grapefruit juice
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Haloperidol
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxyzine
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Imatinib
  • Indacaterol; Glycopyrrolate
  • Indinavir
  • Inotuzumab Ozogamicin
  • Isavuconazonium
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Lefamulin
  • Lenvatinib
  • Letermovir
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levofloxacin
  • Levorphanol
  • Lithium
  • Lofexidine
  • Long-acting beta-agonists
  • Loop diuretics
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lurasidone
  • Macimorelin
  • Mannitol
  • Maprotiline
  • Mefloquine
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Methadone
  • Methazolamide
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Metronidazole
  • Midostaurin
  • Mifepristone
  • Mirabegron
  • Mirtazapine
  • Mitotane
  • Morphine
  • Morphine; Naltrexone
  • Moxifloxacin
  • Nalbuphine
  • Nefazodone
  • Nelfinavir
  • Nilotinib
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ondansetron
  • Oritavancin
  • Orphenadrine
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paliperidone
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pentamidine
  • Pentazocine
  • Pentazocine; Naloxone
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Pimavanserin
  • Pimozide
  • Pitolisant
  • Posaconazole
  • Potassium-sparing diuretics
  • Primaquine
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propantheline
  • Propoxyphene
  • Proton pump inhibitors
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Remifentanil
  • Ribociclib
  • Ribociclib; Letrozole
  • Rilpivirine
  • Risperidone
  • Ritonavir
  • Rivastigmine
  • Rolapitant
  • Romidepsin
  • Saquinavir
  • Scopolamine
  • Selpercatinib
  • Sertraline
  • Short-acting beta-agonists
  • Simeprevir
  • Siponimod
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sufentanil
  • Sunitinib
  • Tacrine
  • Tacrolimus
  • Tamoxifen
  • Tapentadol
  • Tegaserod
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Telotristat Ethyl
  • Tetrabenazine
  • Thiazide diuretics
  • Thioridazine
  • Tipranavir
  • Topiramate
  • Toremifene
  • Tramadol
  • Trandolapril; Verapamil
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Triptorelin
  • Tucatinib
  • Urea
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Voriconazole
  • Vorinostat
  • Warfarin
  • Zafirlukast
  • Ziprasidone
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