Tolmetin

What is Tolmetin

Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) of the acetic acid chemical class.

Tolmetin possesses analgesic and antipyretic properties. Its anti-inflammatory action equates to aspirin, although tolmetin generally is better tolerated.

Tolmetin may have additive effects when used with corticosteroids or other arthritis therapies.

Initial beneficial effects of tolmetin for arthritis may be observed after 5—7 days of use; however, the full beneficial effects may not be observed for several weeks.

Tolmetin was approved by the FDA in March 1976.

Brand Name

Tolectin | Tolectin DS

Indications

  • juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
  • osteoarthritis
  • rheumatoid arthritis

For the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA), or osteoarthritis

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. anemia
  6. angioedema
  7. aseptic meningitis
  8. asthenia
  9. chest pain (unspecified)
  10. confusion
  11. constipation
  12. depression
  13. diarrhea
  14. dizziness
  15. drowsiness
  16. dyspepsia
  17. dysphagia
  18. dysuria
  19. edema
  20. elevated hepatic enzymes
  21. epistaxis
  22. erythema multiforme
  23. esophageal stricture
  24. esophageal ulceration
  25. esophagitis
  26. exfoliative dermatitis
  27. fever
  28. flatulence
  29. fluid retention
  30. gastritis
  31. GI bleeding
  32. GI perforation
  33. glossitis
  34. headache
  35. heart failure
  36. hematuria
  37. hemolytic anemia
  38. hepatitis
  39. hypertension
  40. hyponatremia
  41. interstitial nephritis
  42. jaundice
  43. lymphadenopathy
  44. myocardial infarction
  45. nausea
  46. nephrotic syndrome
  47. odynophagia
  48. optic neuritis
  49. peptic ulcer
  50. photophobia
  51. platelet dysfunction
  52. proteinuria
  53. purpura
  54. pyrosis (heartburn)
  55. renal failure (unspecified)
  56. renal papillary necrosis
  57. serum sickness
  58. skin irritation
  59. Stevens-Johnson syndrome
  60. stomatitis
  61. stroke
  62. thrombocytopenia
  63. thromboembolism
  64. tinnitus
  65. toxic epidermal necrolysis
  66. urticaria
  67. visual impairment
  68. vomiting
  69. weight gain
  70. weight loss

Monitoring Parameters

  • CBC
  • LFTs
  • serum creatinine/BUN
  • stool guaiac

Contraindications

  • acute bronchospasm
  • acute myocardial infarction
  • alcoholism
  • anemia
  • angina
  • anticoagulant therapy
  • asthma
  • bone marrow suppression
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • cerebrovascular disease
  • chemotherapy
  • children
  • coagulopathy
  • coronary artery bypass graft surgery (CABG)
  • coronary artery disease
  • corticosteroid therapy
  • dental disease
  • dental work
  • diabetes mellitus
  • gelatin hypersensitivity
  • geriatric
  • GI bleeding
  • GI disease
  • GI perforation
  • heart failure
  • hematological disease
  • hemophilia
  • hepatic disease
  • hypertension
  • immunosuppression
  • infants
  • intramuscular injections
  • jaundice
  • labor
  • myocardial infarction
  • nasal polyps
  • neonates
  • neutropenia
  • NSAID hypersensitivity
  • obstetric delivery
  • peptic ulcer disease
  • peripheral vascular disease
  • pregnancy
  • proteinuria
  • renal disease
  • renal failure
  • renal impairment
  • rheumatoid arthritis
  • salicylate hypersensitivity
  • stroke
  • systemic lupus erythematosus (SLE)
  • tachycardia
  • thrombocytopenia
  • thromboembolism
  • tobacco smoking
  • ulcerative colitis
  • urticaria

Interactions

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  • Amlodipine; Valsartan
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