What is Tolmetin
Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) of the acetic acid chemical class.
Tolmetin possesses analgesic and antipyretic properties. Its anti-inflammatory action equates to aspirin, although tolmetin generally is better tolerated.
Tolmetin may have additive effects when used with corticosteroids or other arthritis therapies.
Initial beneficial effects of tolmetin for arthritis may be observed after 5—7 days of use; however, the full beneficial effects may not be observed for several weeks.
Tolmetin was approved by the FDA in March 1976.
Brand Name
Tolectin | Tolectin DS
Indications
- juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
- osteoarthritis
- rheumatoid arthritis
For the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA), or osteoarthritis
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- aseptic meningitis
- asthenia
- chest pain (unspecified)
- confusion
- constipation
- depression
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- dysphagia
- dysuria
- edema
- elevated hepatic enzymes
- epistaxis
- erythema multiforme
- esophageal stricture
- esophageal ulceration
- esophagitis
- exfoliative dermatitis
- fever
- flatulence
- fluid retention
- gastritis
- GI bleeding
- GI perforation
- glossitis
- headache
- heart failure
- hematuria
- hemolytic anemia
- hepatitis
- hypertension
- hyponatremia
- interstitial nephritis
- jaundice
- lymphadenopathy
- myocardial infarction
- nausea
- nephrotic syndrome
- odynophagia
- optic neuritis
- peptic ulcer
- photophobia
- platelet dysfunction
- proteinuria
- purpura
- pyrosis (heartburn)
- renal failure (unspecified)
- renal papillary necrosis
- serum sickness
- skin irritation
- Stevens-Johnson syndrome
- stomatitis
- stroke
- thrombocytopenia
- thromboembolism
- tinnitus
- toxic epidermal necrolysis
- urticaria
- visual impairment
- vomiting
- weight gain
- weight loss
Monitoring Parameters
- CBC
- LFTs
- serum creatinine/BUN
- stool guaiac
Contraindications
- acute bronchospasm
- acute myocardial infarction
- alcoholism
- anemia
- angina
- anticoagulant therapy
- asthma
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- cerebrovascular disease
- chemotherapy
- children
- coagulopathy
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- corticosteroid therapy
- dental disease
- dental work
- diabetes mellitus
- gelatin hypersensitivity
- geriatric
- GI bleeding
- GI disease
- GI perforation
- heart failure
- hematological disease
- hemophilia
- hepatic disease
- hypertension
- immunosuppression
- infants
- intramuscular injections
- jaundice
- labor
- myocardial infarction
- nasal polyps
- neonates
- neutropenia
- NSAID hypersensitivity
- obstetric delivery
- peptic ulcer disease
- peripheral vascular disease
- pregnancy
- proteinuria
- renal disease
- renal failure
- renal impairment
- rheumatoid arthritis
- salicylate hypersensitivity
- stroke
- systemic lupus erythematosus (SLE)
- tachycardia
- thrombocytopenia
- thromboembolism
- tobacco smoking
- ulcerative colitis
- urticaria
Interactions
- Abciximab
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetohexamide
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- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amphotericin B
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- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
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- Aspirin, ASA; Pravastatin
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