Tolmetin

What is Tolmetin

Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) of the acetic acid chemical class.

Tolmetin possesses analgesic and antipyretic properties. Its anti-inflammatory action equates to aspirin, although tolmetin generally is better tolerated.

Tolmetin may have additive effects when used with corticosteroids or other arthritis therapies.

Initial beneficial effects of tolmetin for arthritis may be observed after 5—7 days of use; however, the full beneficial effects may not be observed for several weeks.

Tolmetin was approved by the FDA in March 1976.

Brand Name

Tolectin | Tolectin DS

Indications

• juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
• osteoarthritis
• rheumatoid arthritis

For the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA), or osteoarthritis

Side Effects

1. abdominal pain
2. agranulocytosis
3. anaphylactic shock
4. anaphylactoid reactions
5. anemia
6. angioedema
7. aseptic meningitis
8. asthenia
9. chest pain (unspecified)
10. confusion
11. constipation
12. depression
13. diarrhea
14. dizziness
15. drowsiness
16. dyspepsia
17. dysphagia
18. dysuria
19. edema
20. elevated hepatic enzymes
21. epistaxis
22. erythema multiforme
23. esophageal stricture
24. esophageal ulceration
25. esophagitis
26. exfoliative dermatitis
27. fever
28. flatulence
29. fluid retention
30. gastritis
31. GI bleeding
32. GI perforation
33. glossitis
34. headache
35. heart failure
36. hematuria
37. hemolytic anemia
38. hepatitis
39. hypertension
40. hyponatremia
41. interstitial nephritis
42. jaundice
43. lymphadenopathy
44. myocardial infarction
45. nausea
46. nephrotic syndrome
47. odynophagia
48. optic neuritis
49. peptic ulcer
50. photophobia
51. platelet dysfunction
52. proteinuria
53. purpura
54. pyrosis (heartburn)
55. renal failure (unspecified)
56. renal papillary necrosis
57. serum sickness
58. skin irritation
59. Stevens-Johnson syndrome
60. stomatitis
61. stroke
62. thrombocytopenia
63. thromboembolism
64. tinnitus
65. toxic epidermal necrolysis
66. urticaria
67. visual impairment
68. vomiting
69. weight gain
70. weight loss

Monitoring Parameters

• CBC
• LFTs
• serum creatinine/BUN
• stool guaiac

Contraindications

• acute bronchospasm
• acute myocardial infarction
• alcoholism
• anemia
• angina
• anticoagulant therapy
• asthma
• bone marrow suppression
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• chemotherapy
• children
• coagulopathy
• coronary artery bypass graft surgery (CABG)
• coronary artery disease
• corticosteroid therapy
• dental disease
• dental work
• diabetes mellitus
• gelatin hypersensitivity
• geriatric
• GI bleeding
• GI disease
• GI perforation
• heart failure
• hematological disease
• hemophilia
• hepatic disease
• hypertension
• immunosuppression
• infants
• intramuscular injections
• jaundice
• labor
• myocardial infarction
• nasal polyps
• neonates
• neutropenia
• NSAID hypersensitivity
• obstetric delivery
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• proteinuria
• renal disease
• renal failure
• renal impairment
• rheumatoid arthritis
• salicylate hypersensitivity
• stroke
• systemic lupus erythematosus (SLE)
• tachycardia
• thrombocytopenia
• thromboembolism
• tobacco smoking
• ulcerative colitis
• urticaria

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