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What is Telotristat Ethyl
Telotristat ethyl is an orally available tryptophan hydroxylase inhibitor. Tryptophan hydroxylase mediates the rate-limiting step in the formation of serotonin, which is overproduced in patients with carcinoid syndrome and contributes to altered gastrointestinal secretion, motility, inflammation, and sensation.
In a multicenter, randomized, double-blind clinical trial, telotristat ethyl significantly decreased the number of daily bowel movements compared with placebo in patients with well-differentiated metastatic neuroendocrine tumor and carcinoid syndrome diarrhea concurrently treated with a somatostatin analog.
Brand Name
Xermelo
Indications
- carcinoid
For the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in patients inadequately controlled by SSA therapy
Side Effects
- abdominal pain
- anorexia
- constipation
- depression
- elevated hepatic enzymes
- fever
- flatulence
- GI obstruction
- GI perforation
- headache
- nausea
- peripheral edema
Contraindications
- abdominal pain
- breast-feeding
- constipation
- GI obstruction
- GI perforation
- pregnancy
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abiraterone
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Ado-Trastuzumab emtansine
- Alfentanil
- Alfuzosin
- Aliskiren
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- Aliskiren; Valsartan
- Almotriptan
- Alprazolam
- Amiodarone
- Amitriptyline
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- Amlodipine
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- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
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- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cilostazol
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- Cyclosporine
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- Diazepam
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- Ethosuximide
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- Fluticasone; Vilanterol
- Fosamprenavir
- Fosphenytoin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
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- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Imatinib
- Imipramine
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- Isavuconazonium
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- Isradipine
- Itraconazole
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- Ketoconazole
- Ledipasvir; Sofosbuvir
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- Nortriptyline
- Octreotide
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- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oxybutynin
- Oxycodone
- Paclitaxel
- Palonosetron
- Panobinostat
- Paricalcitol
- Pazopanib
- Perampanel
- Perindopril; Amlodipine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenytoin
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- Pirfenidone
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- Praziquantel
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- Primidone
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- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Rabeprazole
- Ramelteon
- Ranolazine
- Repaglinide
- Rifabutin
- Rifampin
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- Riociguat
- Ritonavir
- Rivaroxaban
- Roflumilast
- Rolapitant
- Romidepsin
- Ropivacaine
- Ruxolitinib
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Sertraline
- Sibutramine
- Sildenafil
- Silodosin
- Simeprevir
- Sirolimus
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Sonidegib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Tacrolimus
- Tadalafil
- Tamsulosin
- Tasimelteon
- Telithromycin
- Teniposide
- Terbinafine
- Testosterone
- Theophylline, Aminophylline
- Tiagabine
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- Tinidazole
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- Tolterodine
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triazolam
- Ubrogepant
- Ulipristal
- Umeclidinium; Vilanterol
- Valproic Acid, Divalproex Sodium
- Vemurafenib
- Venlafaxine
- Verapamil
- Vinblastine
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Warfarin
- Yohimbine
- Zileuton
- Ziprasidone
- Zolmitriptan
- Zonisamide
