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What is Telaprevir
Telaprevir is an NS3/4A protease inhibitor, indicated for the treatment of genotype 1 chronic hepatitis C infection in adults with compensated liver disease who are treatment-naive or who have previously had an inadequate responded to interferon-based drug therapy.
Telaprevir must be used in combination with peginterferon alfa and ribavirin; therefore, precautions applying to peginterferon alfa and ribavirin also apply to telaprevir.
Approval of telaprevir was based on the results of two placebo-controlled trials, ADVANCE (treatment-naive patients) and REALIZE (patients with previous inadequate response to interferon-based treatment).
Brand Name
INCIVEK
Indications
- hepatitis C infection
- hepatitis C virus
Side Effects
- anemia
- azotemia
- bullous rash
- diarrhea
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysgeusia
- eosinophilia
- erythema multiforme
- fatigue
- fever
- gout
- hemorrhoids
- hyperbilirubinemia
- hyperuricemia
- leukopenia
- lymphopenia
- nausea
- neutropenia
- pruritus
- pruritus ani
- rash
- rash
- renal failure (unspecified)
- skin erosion
- Stevens-Johnson syndrome
- thrombocytopenia
- toxic epidermal necrolysis
- vesicular rash
- vomiting
Monitoring Parameters
- CBC with differential
- hemoglobin/hematocrit
- LFTs
- plasma hepatitis C RNA
- pregnancy testing
- serum bilirubin
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
- thyroid function tests (TFTs)
Contraindications
- anemia
- breast-feeding
- children
- hepatic disease
- hepatitis C and HIV coinfection
- infants
- liver transplant
- male-mediated teratogenicity
- neonates
- pregnancy
- serious rash
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Ado-Trastuzumab emtansine
- Afatinib
- Aldesleukin, IL-2
- Alfentanil
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alosetron
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Azelastine; Fluticasone
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Bepridil
- Betrixaban
- Bortezomib
- Bosentan
- Bosutinib
- Brexpiprazole
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Caffeine; Ergotamine
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carvedilol
- Cevimeline
- Chloramphenicol
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cilostazol
- Cimetidine
- Cinacalcet
- Cisapride
- Citalopram
- Clarithromycin
- Clofarabine
- Clomipramine
- Clonazepam
- Clozapine
- Cobicistat
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Conjugated Estrogens; Medroxyprogesterone
- Cyclosporine
- Dabigatran
- Danazol
- Dapsone
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Dextromethorphan; Quinidine
- Diazepam
- Diclofenac
- Diclofenac; Misoprostol
- Dienogest; Estradiol valerate
- Digoxin
- Dihydroergotamine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Disulfiram
- Docetaxel
- Dolasetron
- Donepezil
- Donepezil; Memantine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxorubicin
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dutasteride; Tamsulosin
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Eletriptan
- Eliglustat
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Escitalopram
- Eslicarbazepine
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Norethindrone
- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Etravirine
- Ezetimibe; Simvastatin
- Felodipine
- Fesoterodine
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurazepam
- Flutamide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- Fluvoxamine
- Formoterol; Mometasone
- Fosamprenavir
- Galantamine
- Glyburide
- Glyburide; Metformin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Iloperidone
- Imatinib
- Imipramine
- Indinavir
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ivermectin
- Ixabepilone
- Ketoconazole
- Lacosamide
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole
- Lansoprazole; Naproxen
- Leuprolide; Norethindrone
- Levomilnacipran
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lovastatin
- Lovastatin; Niacin
- Macitentan
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Mestranol; Norethindrone
- Metformin; Repaglinide
- Methadone
- Methylergonovine
- Methylprednisolone
- Methysergide
- Midazolam
- Mifepristone
- Mitomycin
- Modafinil
- Mometasone
- Morphine
- Morphine; Naltrexone
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nintedanib
- Nisoldipine
- Norethindrone
- Nortriptyline
- Octreotide
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oritavancin
- Ospemifene
- Oxcarbazepine
- Oxybutynin
- Oxycodone
- Paclitaxel
- Panobinostat
- Paricalcitol
- Pazopanib
- Perampanel
- Pergolide
- Perindopril; Amlodipine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pimozide
- Pitavastatin
- Ponatinib
- Posaconazole
- Prednisolone
- Prednisone
- Primidone
- Propafenone
- Quetiapine
- Quinidine
- Quinine
- Rabeprazole
- Ramelteon
- Ranolazine
- Repaglinide
- Rifabutin
- Rifampin
- Rifaximin
- Riociguat
- Risperidone
- Rivaroxaban
- Romidepsin
- Ropivacaine
- Rosuvastatin
- Ruxolitinib
- Salmeterol
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Sibutramine
- Sildenafil
- Silodosin
- Simvastatin
- Simvastatin; Sitagliptin
- Sirolimus
- Solifenacin
- Sonidegib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Suvorexant
- Tacrolimus
- Tadalafil
- Tamsulosin
- Tasimelteon
- Telithromycin
- Teniposide
- Tenofovir, PMPA
- Terbinafine
- Terfenadine
- Testosterone
- Theophylline, Aminophylline
- Tiagabine
- Ticagrelor
- Tinidazole
- Tipranavir
- Tolterodine
- Tolvaptan
- Trabectedin
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triazolam
- Valbenazine
- Vardenafil
- Vemurafenib
- Venetoclax
- Venlafaxine
- Verapamil
- Vilazodone
- Vinblastine
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Warfarin
- Yohimbine
- Zafirlukast
- Zileuton
- Ziprasidone
- Zolpidem
- Zonisamide
