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What is Sugammadex
Sugammadex is a modified gamma cyclodextrin for the reversal of neuromuscular blockade effects of rocuronium and vecuronium in adults undergoing surgery.
Sugammadex use for reversal of neuromuscular blockade in the intensive care unit or for reversal of nonsteroidal neuromuscular blocking agents or steroidal neuromuscular blocking agents other than rocuronium and vecuronium has not been studied.
Cases of marked bradycardia, some resulting in cardiac arrest, have been observed within minutes of sugammadex administration; hemodynamic parameters should be monitored for changes during and after sugammadex receipt. Sugammadex was FDA-approved in December 2015.
Brand Name
Bridion
Indications
- neuromuscular blockade reversal
The use of sugammadex for neuromuscular blockade reversal following rocuronium or vecuronium administration in the intensive care unit has not been studied.
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- angioedema
- anxiety
- atrial fibrillation
- AV block
- bleeding
- bradycardia
- bronchospasm
- cardiac arrest
- chills
- cough
- depression
- dizziness
- dyspnea
- edema
- erythema
- fever
- flatulence
- flushing
- headache
- hypertension
- hypocalcemia
- hypoesthesia
- hypotension
- insomnia
- laryngospasm
- musculoskeletal pain
- myalgia
- nausea
- pruritus
- pulmonary edema
- QT prolongation
- respiratory arrest
- restlessness
- supraventricular tachycardia (SVT)
- throat irritation
- urticaria
- ventricular fibrillation
- ventricular tachycardia
- vomiting
- wheezing
- xerostomia
Monitoring Parameters
- arterial blood gases (ABGs)
- peripheral nerve stimulation
Contraindications
- bleeding
- bradycardia
- breast-feeding
- coagulopathy
- dialysis
- geriatric
- neuromuscular blockade recurrence
- pregnancy
- renal impairment
- respiratory depression
Interactions
- Conjugated Estrogens; Medroxyprogesterone
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etonogestrel
- Leuprolide; Norethindrone
- Levonorgestrel
- Medroxyprogesterone
- Mestranol; Norethindrone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Segesterone Acetate; Ethinyl Estradiol
- Toremifene
