Sucralfate

What is Sucralfate

Sucralfate is an oral gastrointestinal drug. Chemically, it is a sucrose sulfate complex. Sucralfate is indicated for the short term (up to 8 week) treatment of active duodenal ulcers and is also used as maintenance therapy following resolution of a duodenal ulcer.

The efficacy of sucralfate in the treatment of gastric ulcers is comparable to cimetidine. It has been used in the relief of GI symptoms occurring with NSAIDs, although in one study, sucralfate was significantly less effective than misoprostol.

Other uses for sucralfate include treatment of gastroesophageal reflux disease (GERD) as well as prophylaxis and treatment of stress-induced mucosal damage. Sucralfate was approved by the FDA in 1981.

Brand Name

Carafate

Indications & Dosage

  • aphthous ulcer
  • duodenal ulcer
  • esophagitis
  • gastric ulcer
  • gastroesophageal reflux disease (GERD)
  • NSAID-induced ulcer prophylaxis
  • proctitis
  • stomatitis
  • stress gastritis prophylaxis

For the treatment of duodenal ulcer not related to NSAID use

Side Effects

  1. aluminum toxicity
  2. anaphylactoid reactions
  3. angioedema
  4. back pain
  5. bezoar
  6. constipation
  7. dizziness
  8. drowsiness
  9. dyspnea
  10. edema
  11. flatulence
  12. headache
  13. hyperglycemia
  14. hypophosphatemia
  15. nausea
  16. pruritus
  17. rash
  18. urticaria
  19. vertigo
  20. vomiting
  21. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • diabetes mellitus
  • dialysis
  • dysphagia
  • gag reflex depression
  • geriatric
  • infants
  • intravenous administration
  • neonates
  • pregnancy
  • renal failure
  • renal impairment
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