What is Sucralfate
Sucralfate is an oral gastrointestinal drug. Chemically, it is a sucrose sulfate complex. Sucralfate is indicated for the short term (up to 8 week) treatment of active duodenal ulcers and is also used as maintenance therapy following resolution of a duodenal ulcer.
The efficacy of sucralfate in the treatment of gastric ulcers is comparable to cimetidine. It has been used in the relief of GI symptoms occurring with NSAIDs, although in one study, sucralfate was significantly less effective than misoprostol.
Other uses for sucralfate include treatment of gastroesophageal reflux disease (GERD) as well as prophylaxis and treatment of stress-induced mucosal damage. Sucralfate was approved by the FDA in 1981.
Brand Name
Carafate
Indications & Dosage
- aphthous ulcer
- duodenal ulcer
- esophagitis
- gastric ulcer
- gastroesophageal reflux disease (GERD)
- NSAID-induced ulcer prophylaxis
- proctitis
- stomatitis
- stress gastritis prophylaxis
For the treatment of duodenal ulcer not related to NSAID use
Side Effects
- aluminum toxicity
- anaphylactoid reactions
- angioedema
- back pain
- bezoar
- constipation
- dizziness
- drowsiness
- dyspnea
- edema
- flatulence
- headache
- hyperglycemia
- hypophosphatemia
- nausea
- pruritus
- rash
- urticaria
- vertigo
- vomiting
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- children
- diabetes mellitus
- dialysis
- dysphagia
- gag reflex depression
- geriatric
- infants
- intravenous administration
- neonates
- pregnancy
- renal failure
- renal impairment
- Abacavir; Dolutegravir; Lamivudine
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