Somatropin rh GH

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What is Somatropin rh GH

Somatropin, rh-GH is a purified recombinant growth hormone prepared by using either Escherichia coli or mammalian-cells. Endogenous human growth hormone (hGH) is produced in the pituitary gland.

Growth hormone was first isolated in 1956, and its structure was identified in 1972. Prior to 1985, growth hormone (GH) was derived from human cadavers; however, the use of human derived GH was stopped due to contamination of the product with Creutzfeldt-Jakob virus.

Somatropin is approved for treating growth hormone deficiency (GHD), growth failure, or short stature and for treating cachexia and AIDS wasting; it is also approved for adults with short bowel syndrome.

Somatropin has been studied in the treatment of HIV-associated adipose redistribution syndrome (HARS); limited short-term data indicate use may decrease visceral adipose tissue.

Several somatropin products are available, all with varying indications and dosage regimens. Care should be taken in product selection as products may not be considered interchangeable. Somatropin was originally approved by the FDA in 1987.

Indications & Dosage

  • AIDS-associated wasting syndrome
  • cachexia
  • growth failure
  • growth hormone deficiency
  • HIV-associated lipodystrophy
  • Noonan syndrome
  • Prader-Willi syndrome
  • short bowel syndrome
  • SHOX (short stature homeobox-containing gene) deficiency
  • Turner syndrome

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. alopecia
  4. anaphylactoid reactions
  5. anemia
  6. angioedema
  7. antibody formation
  8. arthralgia
  9. asthenia
  10. back pain
  11. bleeding
  12. carpal tunnel syndrome
  13. chest pain (unspecified)
  14. cough
  15. depression
  16. diabetes mellitus
  17. diabetic ketoacidosis
  18. diaphoresis
  19. diarrhea
  20. dizziness
  21. edema
  22. elevated hepatic enzymes
  23. eosinophilia
  24. erythema
  25. fatigue
  26. fever
  27. fluid retention
  28. gastritis
  29. gynecomastia
  30. headache
  31. hematoma
  32. hematuria
  33. hyperglycemia
  34. hyperlipidemia
  35. hypertension
  36. hypertriglyceridemia
  37. hypoesthesia
  38. hypoglycemia
  39. hypothyroidism
  40. increased intracranial pressure
  41. infection
  42. injection site reaction
  43. insomnia
  44. maculopapular rash
  45. musculoskeletal pain
  46. myalgia
  47. nausea
  48. new primary malignancy
  49. pancreatitis
  50. papilledema
  51. paresthesias
  52. peripheral edema
  53. pruritus
  54. psoriasis
  55. rash
  56. rhinitis
  57. seizures
  58. skin hyperpigmentation
  59. vomiting
  60. weakness

Monitoring Parameters

  • bone age determination
  • growth rate
  • ophthalmologic exam
  • serum growth hormone concentrations
  • thyroid function tests (TFTs)

Contraindications

  • adrenal insufficiency
  • benzyl alcohol hypersensitivity
  • breast-feeding
  • chemotherapy
  • children
  • cresol hypersensitivity
  • diabetes mellitus
  • diabetic retinopathy
  • epiphyseal closure
  • females
  • geriatric
  • glycerin hypersensitivity
  • history of angioedema
  • hypothyroidism
  • increased intracranial pressure
  • neonates
  • neoplastic disease
  • new primary malignancy
  • obesity
  • otitis media
  • pancreatitis
  • pregnancy
  • radiation therapy
  • renal impairment
  • renal osteodystrophy
  • respiratory infection
  • respiratory insufficiency
  • scoliosis
  • serious hypersensitivity reactions or anaphylaxis
  • sleep apnea
  • surgery
  • trauma

Interactions

  • Acarbose
  • Acetohexamide
  • Albiglutide
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Amprenavir
  • Antidiabetic Agents
  • Atazanavir
  • Atazanavir; Cobicistat
  • Azelastine; Fluticasone
  • Beclomethasone
  • Betamethasone
  • Budesonide
  • Budesonide; Formoterol
  • Canagliflozin
  • Canagliflozin; Metformin
  • Chlorpropamide
  • Ciclesonide
  • Corticosteroids
  • Corticotropin, ACTH
  • Cortisone
  • Cyclosporine
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deflazacort
  • Delavirdine
  • Dexamethasone
  • Dulaglutide
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Estrogens
  • Etravirine
  • Exenatide
  • Fludrocortisone
  • Flunisolide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Fosamprenavir
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Hydrocortisone
  • Indinavir
  • Insulin Aspart
  • Insulin Aspart; Insulin Aspart Protamine
  • Insulin Degludec; Liraglutide
  • Insulin Detemir
  • Insulin Glargine
  • Insulin Glargine; Lixisenatide
  • Insulin Glulisine
  • Insulin Lispro
  • Insulin Lispro; Insulin Lispro Protamine
  • Insulin, Inhaled
  • Isophane Insulin (NPH)
  • Lente Insulin
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin
  • Linagliptin; Metformin
  • Liothyronine
  • Liraglutide
  • Lixisenatide
  • Lopinavir; Ritonavir
  • Macimorelin
  • Mecasermin rinfabate
  • Mecasermin, Recombinant, rh-IGF-1
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methylprednisolone
  • Miglitol
  • Mometasone
  • Nateglinide
  • Nelfinavir
  • Nevirapine
  • Non-nucleoside reverse transcriptase inhibitors
  • Ombitasvir; Paritaprevir; Ritonavir
  • Pioglitazone
  • Pramlintide
  • Prednisolone
  • Prednisone
  • Protease inhibitors
  • Regular Insulin
  • Regular Insulin; Isophane Insulin (NPH)
  • Repaglinide
  • Ritonavir
  • Rosiglitazone
  • Saquinavir
  • Saxagliptin
  • Semaglutide
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Testosterone
  • Thyroid hormones
  • Tipranavir
  • Tolazamide
  • Tolbutamide
  • Triamcinolone
  • Ultralente Insulin

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