What is Sodium Hypochlorite
Sodium hypochlorite (household bleach, 5.25%) can be diluted and used as a topical, irrigant antiseptic for cleansing and disinfecting of wounds. It is applied topically, usually by irrigation, soaks, or wet compresses.
Dakin’s solution is a 0.5% (full strength), 0.25% (half strength), or 0.125% (quarter strength) dilution of sodium hypochlorite in water, usually with the addition of boric acid or sodium bicarbonate as buffers to neutralize the pH. Original formulations of Dakin’s solution were first described by Dr. Henry D.
Dakin during World War I, in collaboration with a surgeon, Dr. Alexis Carrel.
Sodium hypochlorite solutions were primarily compounded by pharmacists prior to commercial availability. The irrigant solutions are considered non-prescription (OTC) products in the US.
- Dakins Solution
Indications & Dosage
- skin abrasion
- wound management
For adjunctive wound management of skin abrasion, cuts, and skin ulcers to prevent and treat infections of the skin and tissue, including pre- and post- surgically
- skin irritation
Never use sodium hypochlorite (bleach) directly on the skin. Before use, ensure sodium hypochlorite is diluted to a specified concentration (full strength 0.5%, half strength 0.25%, quarter strength 0.125%). Failure to dilute sodium hypochlorite may result in severe adverse events.
Due to the strong oxidizing property of sodium hypochlorite, skin irritation, erythema, edema, and pain may occur following topical administration. Instruct patients to discontinue therapy and seek medical advice if the above symptoms develop.
- laboratory monitoring not necessary
- accidental exposure
- ocular exposure
There are no drug interactions associated with Sodium Hypochlorite products.