Sodium Ferric Gluconate Complex ferric pyrophosphate citrate

What is Sodium Ferric Gluconate Complex ferric pyrophosphate citrate

Sodium ferric gluconate complex is an injectable iron replacement product indicated for the treatment of iron-deficiency anemia in adults and pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Undiluted sodium ferric gluconate complex may be given without a test dose.

Ferric pyrophosphate citrate is an iron solution for addition to bicarbonate dialysate for the replacement of iron to maintain hemoglobin in adult patients with hemodialysis-dependent chronic kidney disease.

Parenteral iron is preferred over oral iron therapy when rapid repletion of iron-depleted patients is desired. A retrospective analysis of reported adverse medication events indicated a significantly lower mortality rate (p less than 0.001) with the use of sodium ferric gluconate complex compared to iron dextran.

Brand Name

  • Ferrlecit
  • Nulecit
  • Triferic

Indications & Dosage

  • iron-deficiency anemia

For the treatment of iron-deficiency anemia

For the treatment of iron-deficiency anemia in patients undergoing chronic hemodialysis who are receiving supplemental epoetin alfa therapy

Side Effects

  1. abdominal pain
  2. agitation
  3. anaphylactoid reactions
  4. anemia
  5. angina
  6. angioedema
  7. anorexia
  8. arthralgia
  9. asthenia
  10. back pain
  11. bleeding
  12. bradycardia
  13. bronchospasm
  14. cardiac arrest
  15. chest pain (unspecified)
  16. chills
  17. conjunctivitis
  18. constipation
  19. cough
  20. cyanosis
  21. diaphoresis
  22. diarrhea
  23. diplopia
  24. dizziness
  25. drowsiness
  26. dysgeusia
  27. dyspepsia
  28. dyspnea
  29. edema
  30. eructation
  31. fatigue
  32. fever
  33. flank pain
  34. flatulence
  35. flushing
  36. headache
  37. hearing loss
  38. hemosiderosis
  39. hyperhidrosis
  40. hyperkalemia
  41. hypertension
  42. hypertonia
  43. hyperventilation
  44. hypervolemia
  45. hypoesthesia
  46. hypoglycemia
  47. hypokalemia
  48. hypotension
  49. infection
  50. injection site reaction
  51. leukocytosis
  52. lymphadenopathy
  53. malaise
  54. melena
  55. menorrhagia
  56. metabolic acidosis
  57. muscle cramps
  58. musculoskeletal pain
  59. myalgia
  60. myocardial infarction
  61. nausea
  62. pallor
  63. paresthesias
  64. peripheral edema
  65. peripheral vasodilation
  66. pharyngitis
  67. phlebitis
  68. pruritus
  69. pulmonary edema
  70. rhinitis
  71. seizures
  72. sinus tachycardia
  73. skin discoloration
  74. syncope
  75. thrombosis
  76. urticaria
  77. vomiting
  78. weakness
  79. wheezing
  80. xerostomia

Monitoring Parameters

  • ferritin
  • hemoglobin/hematocrit
  • serum iron
  • transferrin

Contraindications

  • benzyl alcohol hypersensitivity
  • breast-feeding
  • cardiac disease
  • children
  • contraception requirements
  • geriatric
  • hemochromatosis
  • hemoglobinopathy
  • hemosiderosis
  • hepatic disease
  • hypotension
  • infants
  • intramuscular administration
  • neonates
  • pregnancy
  • reproductive risk

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Acetohydroxamic Acid
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Antacids
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Omeprazole
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bisphosphonates
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Cefdinir
  • Cholestyramine
  • Cimetidine
  • Ciprofloxacin
  • Darbepoetin Alfa
  • Deferasirox
  • Deferiprone
  • Deferoxamine
  • Delafloxacin
  • Dexlansoprazole
  • Didanosine, ddI
  • Dimercaprol
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Eltrombopag
  • Epoetin Alfa
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Famotidine
  • Famotidine; Ibuprofen
  • Ferric carboxymaltose
  • Ferumoxytol
  • Gemifloxacin
  • Green Tea
  • H2-blockers
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Ibritumomab Tiuxetan
  • Iron – Injectable Only
  • Iron Dextran
  • Iron Sucrose, Sucroferric Oxyhydroxide
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Lanthanum Carbonate
  • Levodopa
  • Levofloxacin
  • Methoxy polyethylene glycol-epoetin beta
  • Methyldopa
  • Moxifloxacin
  • Mycophenolate
  • Nizatidine
  • Norfloxacin
  • Ofloxacin
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Pantoprazole
  • Penicillamine
  • Phosphorated Carbohydrate Solution
  • Phosphorus
  • Potassium Phosphate
  • Potassium Phosphate; Sodium Phosphate
  • Proton pump inhibitors
  • Rabeprazole
  • Ranitidine
  • Sodium Bicarbonate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Tetracyclines
  • Thyroid hormones
  • Trientine
  • Zinc
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