Sipuleucel-T

Sharing is caring!

What is Sipuleucel-T

Sipuleucel-T (Provenge or APC-8015) is an autologous cellular immunotherapy used for the treatment of prostate cancer. 

Brand Name

Provenge

Indications & Dosage

• prostate cancer

For the treatment of asymptomatic or minimally symptomatic metastatic, castrate resistant (hormone refractory), prostate cancer

NOTE: Approximately 3 days prior to each infusion of sipuleucel-T, a standard leukapheresis procedure is to be done. If the patient is unable to receive an infusion of sipuleucel-T and treatment is to be continued, the patient will need to undergo an additional leukapheresis procedure.

NOTE: Prior to infusion of sipuleucel-T, match the patient’s identity with the patient identifiers on both the Cell Product Disposition Form and the sipuleucel-T infusion bag.

Side Effects

1. anemia
2. anorexia
3. arthralgia
4. asthenia
5. back pain
6. bone pain
7. bronchospasm
8. chills
9. constipation
10. cough
11. diarrhea
12. dizziness
13. dyspnea
14. fatigue
15. fever
16. headache
17. hematuria
18. hot flashes
19. hyperhidrosis
20. hypertension
21. hypoxia
22. infection
23. influenza
24. infusion-related reactions
25. insomnia
26. musculoskeletal pain
27. myalgia
28. nausea
29. paresthesias
30. peripheral edema
31. rash
32. stroke
33. tremor
34. vomiting
35. weight loss

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• breast-feeding
• cardiac disease
• chemotherapy
• children
• immunosuppression
• infants
• infusion-related reactions
• neonates
• pregnancy
• pulmonary disease

Interactions

• Antithymocyte Globulin
• Azathioprine
• Basiliximab
• Clozapine
• Cyclosporine
• Dexamethasone
• Efalizumab
• Methylprednisolone
• Muromonab-CD3
• Prednisolone
• Prednisone
• Rituximab
• Rituximab; Hyaluronidase

Sharing is caring!