Sipuleucel-T

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What is Sipuleucel-T

Sipuleucel-T (Provenge or APC-8015) is an autologous cellular immunotherapy used for the treatment of prostate cancer. 

Brand Name

Provenge

Indications & Dosage

  • prostate cancer

For the treatment of asymptomatic or minimally symptomatic metastatic, castrate resistant (hormone refractory), prostate cancer

NOTE: Approximately 3 days prior to each infusion of sipuleucel-T, a standard leukapheresis procedure is to be done. If the patient is unable to receive an infusion of sipuleucel-T and treatment is to be continued, the patient will need to undergo an additional leukapheresis procedure.

NOTE: Prior to infusion of sipuleucel-T, match the patient’s identity with the patient identifiers on both the Cell Product Disposition Form and the sipuleucel-T infusion bag.

Side Effects

  1. anemia
  2. anorexia
  3. arthralgia
  4. asthenia
  5. back pain
  6. bone pain
  7. bronchospasm
  8. chills
  9. constipation
  10. cough
  11. diarrhea
  12. dizziness
  13. dyspnea
  14. fatigue
  15. fever
  16. headache
  17. hematuria
  18. hot flashes
  19. hyperhidrosis
  20. hypertension
  21. hypoxia
  22. infection
  23. influenza
  24. infusion-related reactions
  25. insomnia
  26. musculoskeletal pain
  27. myalgia
  28. nausea
  29. paresthesias
  30. peripheral edema
  31. rash
  32. stroke
  33. tremor
  34. vomiting
  35. weight loss

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • cardiac disease
  • chemotherapy
  • children
  • immunosuppression
  • infants
  • infusion-related reactions
  • neonates
  • pregnancy
  • pulmonary disease

Interactions

  • Antithymocyte Globulin
  • Azathioprine
  • Basiliximab
  • Clozapine
  • Cyclosporine
  • Dexamethasone
  • Efalizumab
  • Methylprednisolone
  • Muromonab-CD3
  • Prednisolone
  • Prednisone
  • Rituximab
  • Rituximab; Hyaluronidase

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