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What is Rosuvastatin
Rosuvastatin is a selective, competitive, HMG-CoA reductase inhibitor. It potently reduces total and LDL cholesterol and lowers plasma triglycerides and apolipoprotein B (Apo-B).
Because of its chemical structure binding sites and relatively greater hydrophilicity, it appears to better penetrate the hepatocyte and bind to HMG-CoA reductase with a higher affinity than other statins.
In adult patients with primary hypercholesterolemia, dose-related LDL-reduction is 45% with 5 mg, 52% with 10mg, 55% with 20 mg, and 63% with 40 mg; doses of 5 to 40 mg/day lower triglycerides by 21% to 43%. Similar to other statins, rosuvastatin produces modest increases in HDL (8% to 12%).
Brand Names
- Crestor
- Ezallor
Indications
- atherosclerosis
- hypercholesterolemia
- hyperlipoproteinemia
- hypertriglyceridemia
- myocardial infarction prophylaxis
- stroke prophylaxis
For the treatment of hypercholesterolemia, including hyperlipidemia, hyperlipoproteinemia, or hypertriglyceridemia, as an adjunct to dietary control
for reduction of elevated total cholesterol, LDL-cholesterol, apolipoprotein B, and triglyceride concentrations, and to increase HDL-cholesterol in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) or mixed dyslipidemia (Fredrickson types IIa or IIb); or to treat Fredrickson Type IV (hypertriglyceridemia, increased VLDL); or to treat primary dysbetalipoproteinemia (Type III hyperlipoproteinemia)
Side Effects
- abdominal pain
- alopecia
- amnesia
- anaphylactoid reactions
- angioedema
- arthralgia
- asthenia
- chills
- cholestasis
- Co-Enzyme Q-10 deficiency
- confusion
- constipation
- depression
- diabetes mellitus
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- fever
- flushing
- headache
- hematuria
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperglycemia
- immune-mediated necrotizing myopathy
- insomnia
- interstitial lung disease
- jaundice
- leukopenia
- lupus-like symptoms
- malaise
- memory impairment
- muscle cramps
- myalgia
- myasthenia
- myoglobinuria
- nausea
- nightmares
- pancreatitis
- peripheral neuropathy
- photosensitivity
- proteinuria
- pruritus
- purpura
- rash
- renal failure (unspecified)
- rhabdomyolysis
- Stevens-Johnson syndrome
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vasculitis
Monitoring Parameters
- creatine phosphokinase (CPK)
- LFTs
- serum cholesterol profile
- serum creatinine
Contraindications
- alcoholism
- Asian patients
- breast-feeding
- children
- contraception requirements
- diabetes mellitus
- electrolyte imbalance
- endocrine disease
- females
- geriatric
- hepatic disease
- hepatic encephalopathy
- hepatitis
- hypotension
- hypothyroidism
- infants
- infection
- jaundice
- myopathy
- pregnancy
- renal disease
- renal failure
- renal impairment
- reproductive risk
- rhabdomyolysis
- seizure disorder
- surgery
- trauma
Interactions
- Acalabrutinib
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Antacids
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Atazanavir
- Atazanavir; Cobicistat
- Bortezomib
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Capmatinib
- Cimetidine
- Clarithromycin
- Clofarabine
- Cobicistat
- Colchicine
- Colchicine; Probenecid
- Cyclosporine
- Daclatasvir
- Daptomycin
- Darolutamide
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eltrombopag
- Eluxadoline
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Erythromycin
- Erythromycin; Sulfisoxazole
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etravirine
- Fenofibrate
- Fenofibric Acid
- Fosamprenavir
- Fostamatinib
- Gemfibrozil
- Glecaprevir; Pibrentasvir
- Indinavir
- Itraconazole
- Lanthanum Carbonate
- Ledipasvir; Sofosbuvir
- Leflunomide
- Letermovir
- Lopinavir; Ritonavir
- Lovastatin; Niacin
- Mestranol; Norethindrone
- Nelfinavir
- Niacin, Niacinamide
- Niacin; Simvastatin
- Norgestrel
- Obeticholic Acid
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Sodium Bicarbonate
- Oritavancin
- Osimertinib
- Ponatinib
- Raltegravir
- Red Yeast Rice
- Regorafenib
- Ritonavir
- Rolapitant
- Safinamide
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Simeprevir
- Sodium Bicarbonate
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Tacrolimus
- Tafamidis
- Tedizolid
- Telaprevir
- Telbivudine
- Telithromycin
- Teriflunomide
- Tipranavir
- Tolvaptan
- Warfarin
