Rizatriptan (MK-462)

What is Rizatriptan

Rizatriptan (MK-462) is a central serotonin-receptor 1B and 1D agonist. It is indicated for the treatment of acute migraine attacks with or without aura.

Rizatriptan is not indicated for prophylactic therapy of migraine or for the treatment of hemiplegic or basilar migraines or cluster headaches.

The efficacy and side effect profile of rizatriptan seems to be dose-dependent with the 10 mg dose being slightly more effective and causing a slight increase in adverse effects as compared to the 5 mg dose. 

Brand Name

• Maxalt
• Maxalt-MLT

Indications

• migraine

For the treatment of acute migraine attacks with or without aura

Side Effects

1. acne vulgaris
2. agitation
3. akinesia
4. angina
5. angioedema
6. anorexia
7. anxiety
8. appetite stimulation
9. arrhythmia exacerbation
10. arthralgia
11. asthenia
12. ataxia
13. blurred vision
14. bowel ischemia
15. bradycardia
16. chest pain (unspecified)
17. chest pressure syndrome
18. chills
19. confusion
20. constipation
21. coronary vasospasm
22. cough
23. dehydration
24. depression
25. diarrhea
26. dizziness
27. drowsiness
28. dysarthria
29. dysesthesia
30. dysgeusia
31. dyspepsia
32. dysphagia
33. dyspnea
34. dysuria
35. edema
36. epistaxis
37. eructation
38. erythema
39. euphoria
40. fatigue
41. fever
42. flatulence
43. gastritis
44. gastroesophageal reflux
45. headache
46. heat intolerance
47. hiccups
48. hoarseness
49. hot flashes
50. hyperacusis
51. hyperesthesia
52. hyperhidrosis
53. hyperkinesis
54. hypertension
55. hyperthermia
56. hypoesthesia
57. hyporeflexia
58. increased intracranial pressure
59. increased urinary frequency
60. infection
61. insomnia
62. intracranial bleeding
63. irritability
64. lacrimation
65. memory impairment
66. menstrual irregularity
67. muscle cramps
68. muscle paralysis
69. musculoskeletal pain
70. myalgia
71. myasthenia
72. myocardial infarction
73. nasal congestion
74. nasal dryness
75. nasal irritation
76. nausea
77. ocular inflammation
78. ocular irritation
79. ocular pain
80. ocular pruritus
81. otalgia
82. palpitations
83. paresthesias
84. parosmia
85. peripheral vasoconstriction
86. pharyngitis
87. photophobia
88. photopsia
89. photosensitivity
90. polydipsia
91. polyuria
92. pruritus
93. rash
94. rhinorrhea
95. seizures
96. serotonin syndrome
97. sinus tachycardia
98. sneezing
99. stroke
100. syncope
101. tachypnea
102. throat irritation
103. tinnitus
104. toxic epidermal necrolysis
105. tremor
106. urticaria
107. vertigo
108. vomiting
109. wheezing
110. withdrawal
111. xerophthalmia
112. xerostomia
113. yawning

Monitoring Parameters

• ECG

Contraindications

• acute myocardial infarction
• angina
• arteriosclerosis
• basilar/hemiplegic migraine
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cerebrovascular disease
• children
• colitis
• coronary artery disease
• diabetes mellitus
• dialysis
• driving or operating machinery
• geriatric
• hepatic disease
• hypercholesterolemia
• hypertension
• infants
• intracranial bleeding
• MAOI therapy
• neonates
• obesity
• peripheral vascular disease
• phenylketonuria
• pregnancy
• Raynaud’s phenomenon
• renal disease
• renal failure
• renal impairment
• stroke
• tobacco smoking
• vasospastic angina
• Wolff-Parkinson-White syndrome

Interactions

• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Tramadol
• Alfentanil
• Almotriptan
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzhydrocodone; Acetaminophen
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Bromocriptine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Buspirone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Citalopram
• Clomipramine
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Desipramine
• Desvenlafaxine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dextroamphetamine
• Dextromethorphan
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Doxepin
• Droxidopa
• Duloxetine
• Eletriptan
• Ergot alkaloids
• Escitalopram
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluvoxamine
• Frovatriptan
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Homatropine; Hydrocodone
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Imipramine
• Isocarboxazid
• Lasmiditan
• Levomilnacipran
• Levorphanol
• Linezolid
• Lisdexamfetamine
• Lithium
• Lorcaserin
• Meperidine
• Meperidine; Promethazine
• Methadone
• Methamphetamine
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methylene Blue
• Milnacipran
• Mirtazapine
• Morphine
• Morphine; Naltrexone
• Nalbuphine
• Naproxen; Sumatriptan
• Naratriptan
• Nefazodone
• Nortriptyline
• Oxycodone
• Oxymorphone
• Ozanimod
• Paroxetine
• Perphenazine; Amitriptyline
• Phenelzine
• Propranolol
• Protriptyline
• Rasagiline
• Remifentanil
• Selective serotonin reuptake inhibitors
• Selegiline
• Sertraline
• Sibutramine
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sumatriptan
• Tapentadol
• Tedizolid
• Tramadol
• Tranylcypromine
• Trazodone
• Tricyclic antidepressants
• Trimipramine
• Venlafaxine
• Vilazodone
• Vortioxetine
• Zolmitriptan