Rabies Immune Globulin (human RIG)

What is Rabies Immune Globulin (human RIG)

Rabies immune globulin, human RIG is a parenteral gamma globulin prepared from the plasma of donors who have been hyperimmunized with rabies vaccine.

Rabies immune globulin, human RIG is indicated for postexposure prophylaxis, along with the rabies vaccine, for persons suspected of rabies exposure (both bite and nonbite) regardless of the time interval between exposure and initiation of postexposure prophylaxis.

In previously unvaccinated patients, administering the immune globulin in conjunction with the vaccine provides immediate, passive rabies virus neutralizing antibody coverage until the patient responds to the rabies vaccine by actively producing antibodies.

If more than 7 days have passed since rabies vaccine was administered, rabies immune globulin is not indicated as an antibody response to the vaccine is presumed to have occurred.

Avoid use of the rabies immune globulin, human RIG in patients previously immunized with rabies vaccine in a preexposure or postexposure treatment series who have a confirmed adequate rabies antibody titer; previously vaccinated patients should receive only rabies vaccine.

Indications

  • rabies prophylaxis
  • rabies virus

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. angioedema
  4. arthralgia
  5. chills
  6. diarrhea
  7. dizziness
  8. erythema
  9. fatigue
  10. fever
  11. flatulence
  12. headache
  13. hematuria
  14. hypoesthesia
  15. hypotension
  16. infection
  17. injection site reaction
  18. malaise
  19. myalgia
  20. nasal congestion
  21. nausea
  22. nephrotic syndrome
  23. photosensitivity
  24. pruritus
  25. pyuria
  26. rash
  27. sinus tachycardia
  28. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • anticoagulant therapy
  • breast-feeding
  • children
  • coagulopathy
  • geriatric
  • hemolysis
  • hemophilia
  • hypertriglyceridemia
  • IgA deficiency
  • infants
  • intravenous administration
  • laboratory test interference
  • neonates
  • pregnancy
  • thrombocytopenia
  • viral infection
  • vitamin K deficiency

Interactions

  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Rabies Vaccine
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Varicella-Zoster Virus Vaccine, Live
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