What is Rabies Immune Globulin (human RIG)
Rabies immune globulin, human RIG is a parenteral gamma globulin prepared from the plasma of donors who have been hyperimmunized with rabies vaccine.
Rabies immune globulin, human RIG is indicated for postexposure prophylaxis, along with the rabies vaccine, for persons suspected of rabies exposure (both bite and nonbite) regardless of the time interval between exposure and initiation of postexposure prophylaxis.
In previously unvaccinated patients, administering the immune globulin in conjunction with the vaccine provides immediate, passive rabies virus neutralizing antibody coverage until the patient responds to the rabies vaccine by actively producing antibodies.
If more than 7 days have passed since rabies vaccine was administered, rabies immune globulin is not indicated as an antibody response to the vaccine is presumed to have occurred.
Avoid use of the rabies immune globulin, human RIG in patients previously immunized with rabies vaccine in a preexposure or postexposure treatment series who have a confirmed adequate rabies antibody titer; previously vaccinated patients should receive only rabies vaccine.
Indications
- rabies prophylaxis
- rabies virus
Side Effects
- abdominal pain
- anaphylactoid reactions
- angioedema
- arthralgia
- chills
- diarrhea
- dizziness
- erythema
- fatigue
- fever
- flatulence
- headache
- hematuria
- hypoesthesia
- hypotension
- infection
- injection site reaction
- malaise
- myalgia
- nasal congestion
- nausea
- nephrotic syndrome
- photosensitivity
- pruritus
- pyuria
- rash
- sinus tachycardia
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- anticoagulant therapy
- breast-feeding
- children
- coagulopathy
- geriatric
- hemolysis
- hemophilia
- hypertriglyceridemia
- IgA deficiency
- infants
- intravenous administration
- laboratory test interference
- neonates
- pregnancy
- thrombocytopenia
- viral infection
- vitamin K deficiency
Interactions
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Rabies Vaccine
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Varicella-Zoster Virus Vaccine, Live
