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What is Retapamulin
Retapamulin is a topical pleuromutilin antibiotic indicated for the treatment of impetigo due to Staphylococcus aureus (methicillin-susceptible isolates only) and Streptococcus pyogenes.
It is a semisynthetic derivative of the compound pleuromutilin, which is isolated through fermentation from Clitopilus passeckerianus.
Retapamulin ointment application twice daily for 5 days was shown to be at least as effective as 10 days of twice-daily oral cephalexin for the treatment of secondarily infected traumatic skin lesions.
Absorption in pediatric patients may be greater than adult patients. Safety in patients younger than 9 months has not been established.
Brand Name
ALTABAX
Indications
- impetigo
- Staphylococcus aureus (MSSA)
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
Side Effects
- contact dermatitis
- diarrhea
- eczema vaccinatum
- erythema
- fever
- headache
- nausea
- pharyngitis
- pruritus
- skin irritation
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- ophthalmic administration
- pregnancy
- vaginal administration
Interactions
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Atazanavir
- Atazanavir; Cobicistat
- Ceritinib
- Chloramphenicol
- Clarithromycin
- Cobicistat
- Conivaptan
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Fosamprenavir
- grapefruit juice
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Lopinavir; Ritonavir
- Mifepristone
- Nefazodone
- Nelfinavir
- Ombitasvir; Paritaprevir; Ritonavir
- Posaconazole
- Ribociclib
- Ribociclib; Letrozole
- Ritonavir
- Saquinavir
- Telithromycin
- Tipranavir
- Tucatinib
- Voriconazole
