Quazepam

What is Quazepam

Quazepam is a long-acting oral benzodiazepine used for the short-term treatment of insomnia.

It has been shown to be effective in both sleep laboratory studies and larger clinical trials.

The clinical data collected from sleep laboratory studies support the subjective effects reported by patients, which indicate increased quality as well as quantity of sleep.

Overall, quazepam increases total sleep time. It has been shown to be very well tolerated.

Daytime drowsiness has been the most commonly reported adverse effect, which is usually mild and is generally limited to the first few days of therapy, and unlike the shorter acting agents such as triazolam and temazepam, is rarely associated with rebound insomnia.

Quazepam was approved by the FDA for the short-term treatment of insomnia in 1985.

Brand Name

Doral

Indications & Dosage

• insomnia

For the treatment of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings

Side Effects

1. abdominal pain
2. agitation
3. amnesia
4. anaphylactoid reactions
5. angioedema
6. anorexia
7. anxiety
8. asthenia
9. ataxia
10. blurred vision
11. cataracts
12. complex sleep-related behaviors
13. confusion
14. constipation
15. depression
16. diarrhea
17. dizziness
18. drowsiness
19. dysarthria
20. dysgeusia
21. dyspepsia
22. elevated hepatic enzymes
23. euphoria
24. fatigue
25. headache
26. hyperkinesis
27. hypotension
28. impotence (erectile dysfunction)
29. irritability
30. jaundice
31. libido decrease
32. malaise
33. memory impairment
34. nausea
35. neonatal abstinence syndrome
36. neonatal respiratory depression
37. nightmares
38. palpitations
39. paranoia
40. physiological dependence
41. pruritus
42. psychological dependence
43. rash
44. respiratory depression
45. somnambulism
46. teratogenesis
47. tolerance
48. tremor
49. urinary incontinence
50. visual impairment
51. withdrawal
52. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• alcoholism
• benzodiazepine dependence
• benzodiazepine hypersensitivity
• bipolar disorder
• breast-feeding
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• CNS depression
• coadministration with other CNS depressants
• complex sleep-related behaviors
• dementia
• depression
• driving or operating machinery
• ethanol ingestion
• ethanol intoxication
• geriatric
• hepatic disease
• infants
• labor
• mania
• myasthenia gravis
• neonates
• obstetric delivery
• pain
• Parkinson’s disease
• porphyria
• pregnancy
• psychosis
• pulmonary disease
• renal failure
• renal impairment
• respiratory depression
• respiratory insufficiency
• seizure disorder
• seizures
• sleep apnea
• status epilepticus
• substance abuse
• suicidal ideation

Interactions

• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acrivastine; Pseudoephedrine
• Aldesleukin, IL-2
• Alfentanil
• Alprazolam
• Amiodarone
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amprenavir
• Apalutamide
• Apomorphine
• Apraclonidine
• Aprepitant, Fosaprepitant
• Aripiprazole
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Atazanavir
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• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
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• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
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• Cetirizine; Pseudoephedrine
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• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chlorcyclizine
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorthalidone; Clonidine
• Cimetidine
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• Clemastine
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• Dexmedetomidine
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• Dextromethorphan; Guaifenesin; Phenylephrine
• Dicyclomine
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• Diltiazem
• Dimenhydrinate
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• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disulfiram
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• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
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• Drospirenone; Ethinyl Estradiol; Levomefolate
• Efavirenz
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• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elbasvir; Grazoprevir
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• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Enflurane
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• Erythromycin
• Erythromycin; Sulfisoxazole
• Esketamine
• Eszopiclone
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Ethotoin
• Etomidate
• Fentanyl
• Fluconazole
• Flumazenil
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluvoxamine
• food
• Fosamprenavir
• Fosphenytoin
• Fospropofol
• Gabapentin
• General anesthetics
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guanabenz
• Guanfacine
• Haloperidol
• Halothane
• Homatropine; Hydrocodone
• Hydantoins
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxyzine
• Ibuprofen; Oxycodone
• Idelalisib
• Iloperidone
• Imatinib
• Indinavir
• Isavuconazonium
• Isoflurane
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Itraconazole
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• Levorphanol
• Lithium
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• Lumateperone
• Lurasidone
• Magnesium Salts
• Maprotiline
• Meclizine
• Melatonin
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• Meperidine; Promethazine
• Mephobarbital
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• Morphine
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• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Oritavancin
• Oxybutynin
• Oxycodone
• Oxymorphone
• Paliperidone
• Pancuronium
• Papaverine
• Pazopanib
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Phenobarbital
• Phenothiazines
• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Phenytoin
• Pimozide
• Posaconazole
• Pramipexole
• Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
• Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
• Pregabalin
• Primidone
• Probenecid
• Procarbazine
• Propofol
• Propoxyphene
• Protease inhibitors
• Quetiapine
• Ramelteon
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• Rapacuronium
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• Scopolamine
• Secobarbital
• Sedating H1-blockers
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• Sevoflurane
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• St. John’s Wort, Hypericum perforatum
• Succinylcholine
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• Topiramate
• Tramadol
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