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Pregabalin Brand Names- Lyrica | Lyrica CR
What is Pregabalin
Pregabalin is indicated for neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, postherpetic neuralgia, fibromyalgia, and adjunctive therapy for partial onset seizures.
Pregabalin is an oral compound that is chemically and structurally similar to gabapentin, with antiepileptic, analgesic, and anxiolytic properties.
Antiepileptic drugs, including pregabalin, are associated with an increased risk of suicidal thoughts and behaviors; patients should be monitored for new or worsening depression, suicidal thoughts and/or behaviors, and changes in mood or behavior.
Indications
- diabetic neuropathy
- fibromyalgia
- generalized anxiety disorder (GAD)
- neuropathic pain
- partial seizures
- postherpetic neuralgia
- social phobia (social anxiety disorder)
- spinal cord injury
NOTE: If pregabalin dose is reduced, discontinued, or substituted with an alternative medication, this should be done gradually over a minimum interval of 1 week.
For the symptomatic treatment of neuropathic pain
for pain associated with peripheral diabetic neuropathy (DPN)
Side Effects
- abdominal pain
- acute cerebellar syndrome
- agitation
- alopecia
- amblyopia
- amenorrhea
- amnesia
- anaphylactoid reactions
- anemia
- angioedema
- anxiety
- aphasia
- apnea
- appetite stimulation
- arthralgia
- ascites
- asthenia
- ataxia
- back pain
- blepharitis
- blurred vision
- breast enlargement
- bullous rash
- cervicitis
- chest pain (unspecified)
- chills
- cholecystitis
- cholelithiasis
- colitis
- coma
- confusion
- conjunctivitis
- constipation
- contact dermatitis
- cough
- crystalluria
- delirium
- depression
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysarthria
- dysgeusia
- dyskinesia
- dysmenorrhea
- dyspareunia
- dysphagia
- dyspnea
- dystonic reaction
- dysuria
- ecchymosis
- edema
- ejaculation dysfunction
- elevated hepatic enzymes
- encephalopathy
- eosinophilia
- epididymitis
- esophageal ulceration
- esophagitis
- euphoria
- exfoliative dermatitis
- exophthalmos
- fatigue
- fever
- flatulence
- fluid retention
- gastritis
- GI bleeding
- glycosuria
- Guillain-Barre syndrome
- gynecomastia
- hallucinations
- headache
- heart failure
- hematuria
- hiccups
- hirsutism
- hostility
- hyperacusis
- hyperalgesia
- hyperesthesia
- hyperkinesis
- hypersalivation
- hypertension
- hypertonia
- hypoesthesia
- hypoglycemia
- hypotension
- hypotonia
- impotence (erectile dysfunction)
- increased intracranial pressure
- increased urinary frequency
- infection
- infertility
- insomnia
- iritis
- irritability
- keratitis
- keratoconjunctivitis
- laryngeal edema
- lethargy
- leukocytosis
- leukopenia
- leukorrhea
- libido decrease
- libido increase
- lymphadenopathy
- malaise
- mania
- melena
- memory impairment
- menorrhagia
- miosis
- muscle cramps
- myalgia
- myasthenia
- mydriasis
- myoclonia
- myopathy
- nausea
- neuritis
- new primary malignancy
- night blindness
- nystagmus
- ocular hemorrhage
- oliguria
- optic atrophy
- oral ulceration
- orgasm dysfunction
- orthostatic hypotension
- palpitations
- pancreatitis
- papilledema
- paranoia
- paresthesias
- parosmia
- pelvic pain
- peripheral edema
- peripheral neuropathy
- pharyngitis
- phlebitis
- photophobia
- photosensitivity
- physiological dependence
- polycythemia
- proteinuria
- pruritus
- psychomotor impairment
- psychosis
- ptosis
- pulmonary edema
- pulmonary fibrosis
- purpura
- rash
- renal failure (unspecified)
- respiratory depression
- retinal edema
- retroperitoneal fibrosis
- rhabdomyolysis
- sinus tachycardia
- sinusitis
- skin atrophy
- skin necrosis
- skin ulcer
- Stevens-Johnson syndrome
- stomatitis
- suicidal ideation
- syncope
- thrombocytopenia
- tinnitus
- torticollis
- tremor
- trismus
- urinary incontinence
- urinary retention
- urticaria
- uveitis
- ventricular fibrillation
- vertigo
- vesicular rash
- visual impairment
- vomiting
- weight gain
- wheezing
- withdrawal
- xerophthalmia
- xerosis
- xerostomia
- yawning
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- angioedema
- breast-feeding
- chronic obstructive pulmonary disease (COPD)
- CNS depression
- coadministration with other CNS depressants
- depression
- diabetes mellitus
- driving or operating machinery
- ethanol intoxication
- geriatric
- heart failure
- labor
- obstetric delivery
- ocular disease
- pregnancy
- pulmonary disease
- renal failure
- renal impairment
- reproductive risk
- respiratory depression
- substance abuse
- suicidal ideation
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Alogliptin; Pioglitazone
- Alprazolam
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Benazepril
- Amobarbital
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Angiotensin-converting enzyme inhibitors
- Apomorphine
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzphetamine
- Brexpiprazole
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Cannabidiol
- Capsaicin; Metaxalone
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloral Hydrate
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Clemastine
- Clobazam
- Clomipramine
- Clonazepam
- Clonidine
- Clorazepate
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dantrolene
- Desipramine
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Diazepam
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Esketamine
- Estazolam
- Eszopiclone
- Ethanol
- Ezogabine
- Fenfluramine
- Fentanyl
- Flibanserin
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Gabapentin
- General anesthetics
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxychloroquine
- Hydroxyzine
- Ibuprofen; Oxycodone
- Iloperidone
- Imipramine
- Isocarboxazid
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levodopa
- Levorphanol
- Lisdexamfetamine
- Lisinopril
- Lofexidine
- Lorazepam
- Loxapine
- Lumateperone
- Lurasidone
- Maprotiline
- Meclizine
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Metaxalone
- Metformin; Pioglitazone
- Metformin; Rosiglitazone
- Methadone
- Methamphetamine
- Methocarbamol
- Methohexital
- Methyldopa
- Metoclopramide
- Midazolam
- Mirtazapine
- Moexipril
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nefazodone
- Nortriptyline
- Olanzapine
- Orphenadrine
- Oxazepam
- Oxycodone
- Oxymorphone
- Paliperidone
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pioglitazone
- Pramipexole
- Primidone
- Prochlorperazine
- Promethazine
- Propoxyphene
- Protriptyline
- Quazepam
- Quetiapine
- Quinapril
- Ramelteon
- Ramipril
- Rasagiline
- Remifentanil
- Risperidone
- Ropinirole
- Rosiglitazone
- Rotigotine
- Safinamide
- Scopolamine
- Secobarbital
- Selegiline
- Sodium Oxybate
- Sufentanil
- Suvorexant
- Tapentadol
- Tasimelteon
- Temazepam
- Tetrabenazine
- Thalidomide
- Thiazolidinediones
- Thiopental
- Thioridazine
- Thiothixene
- Tizanidine
- Topiramate
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triprolidine
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Zaleplon
- Ziprasidone
- Zolpidem
