Potassium Chloride

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Potassium Chloride Brand Names

Cena K | ED-K+10 | Epiklor | K Plus | K Plus Care | K-10 | K-8 | Kaon-CL | Kay Ciel | K-Dur | K-Lor | Klor-Con | Klor-Con M10 | Klor-Con M15 | Klor-Con M20 | Klotrix | K-Lyte CL | K-Sol | K-Tab | Micro-K | Micro-K Extencaps | PROAMP | Rum-K | Slow-K | Tri-K

What is Potassium Chloride

Potassium is the primary intracellular cation. It plays a major role in muscle and nerve cell electrodynamics. Its concentration inside the cell (roughly 150 to 160 mEq/L) is 25 to 35 times greater than extracellular concentrations.

Hypokalemia is generally defined as a serum potassium concentration less than 3.5 mEq/liter.

However, the National Council on Potassium in Clinical Practice recommends that serum potassium concentrations of at least 4 mEq/L be achieved and maintained in patients with hypertension, heart failure, and cardiac arrhythmias.

In addition, the Council recommends potassium supplementation for patients at risk for developing hypokalemia and associated complications (e.g., patients with potential for diuretic-induced potassium loss, patients sensitive to sodium or with high sodium intake, and patients with reduced GI intake or GI disturbances [e.g., vomiting, diarrhea]).

Due to the potential to cause significant harm when used in error, strictly adhere to dilution and administration guidelines for intravenous potassium chloride

Indications

  1. diabetic ketoacidosis
  2. digoxin toxicity
  3. hypokalemia
  4. hypokalemia prevention
  5. nutritional supplementation

Side Effects

  1. abdominal pain
  2. aluminum toxicity
  3. anaphylactoid reactions
  4. angioedema
  5. anxiety
  6. arrhythmia exacerbation
  7. asystole
  8. AV block
  9. bradycardia
  10. cardiac arrest
  11. chest pain (unspecified)
  12. chills
  13. confusion
  14. diarrhea
  15. dysphagia
  16. dyspnea
  17. encephalopathy
  18. erythema
  19. esophageal stricture
  20. esophageal ulceration
  21. esophagitis
  22. fatigue
  23. fever
  24. flatulence
  25. GI bleeding
  26. GI obstruction
  27. GI perforation
  28. glycosuria
  29. hyperglycemia
  30. hyperkalemia
  31. hypervolemia
  32. hyponatremia
  33. hyporeflexia
  34. hypotension
  35. infection
  36. injection site reaction
  37. lethargy
  38. metabolic acidosis
  39. muscle paralysis
  40. nausea
  41. odynophagia
  42. paresthesias
  43. phlebitis
  44. rash
  45. seizures
  46. skin necrosis
  47. skin ulcer
  48. thrombosis
  49. tissue necrosis
  50. ventricular fibrillation
  51. vomiting
  52. weakness

Monitoring Parameters

  • ECG
  • serum bicarbonate
  • serum chloride
  • serum creatinine/BUN
  • serum potassium

Contraindications

  • adrenal insufficiency
  • atrial fibrillation
  • atrial flutter
  • AV block
  • breast-feeding
  • burns
  • cardiac arrhythmias
  • children
  • dehydration
  • diabetic ketoacidosis
  • digitalis toxicity
  • electrolyte imbalance
  • encephalopathy
  • esophageal stricture
  • extravasation
  • gastroparesis
  • geriatric
  • GI obstruction
  • heart failure
  • hyperkalemia
  • hypervolemia
  • hyponatremia
  • ileus
  • metabolic acidosis
  • muscle channelopathy
  • peptic ulcer disease
  • peripheral edema
  • pregnancy
  • premature neonates
  • pulmonary disease
  • pulmonary edema
  • renal disease
  • renal failure
  • renal impairment
  • thrombophlebitis
  • ventricular arrhythmias
  • ventricular fibrillation
  • ventricular tachycardia

Potassium chloride is contraindicated in patients with known hypersensitivity to any potassium formulation.

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Ammonium Chloride
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anticholinergics
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Benztropine
  • Betamethasone
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Budesonide
  • Budesonide; Formoterol
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Celecoxib
  • Chlordiazepoxide; Clidinium
  • Chlorpropamide
  • Choline Salicylate; Magnesium Salicylate
  • Ciclesonide
  • Colchicine
  • Colchicine; Probenecid
  • Corticosteroids
  • Cortisone
  • Cyclosporine
  • Deflazacort
  • Dexamethasone
  • Dextromethorphan; Quinidine
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dicyclomine
  • Diflunisal
  • Digoxin
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Donepezil; Memantine
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Eplerenone
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Esomeprazole; Naproxen
  • Etodolac
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Flavoxate
  • Flecainide
  • Fludrocortisone
  • Flunisolide
  • Flurbiprofen
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • food
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Heparin
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Ibuprofen
  • Hydrocortisone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Indacaterol; Glycopyrrolate
  • Indomethacin
  • Irbesartan
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lisdexamfetamine
  • Lisinopril
  • Lithium
  • Loperamide
  • Loperamide; Simethicone
  • Losartan
  • Magnesium Salicylate
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Memantine
  • Mepenzolate
  • Methamphetamine
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Methylprednisolone
  • Moexipril
  • Mometasone
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nebivolol; Valsartan
  • Nonsteroidal antiinflammatory drugs
  • Olmesartan
  • Oxaprozin
  • Oxybutynin
  • Penicillin G
  • Perindopril
  • Perindopril; Amlodipine
  • Piroxicam
  • Prednisolone
  • Prednisone
  • Propantheline
  • Quinapril
  • Quinidine
  • Quinine
  • Ramipril
  • Rofecoxib
  • Sacubitril; Valsartan
  • Salicylates
  • Salsalate
  • Scopolamine
  • Sodium Polystyrene Sulfonate
  • Spironolactone
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulindac
  • Tacrolimus
  • Telmisartan
  • Tolmetin
  • Tolvaptan
  • Trandolapril
  • Trandolapril; Verapamil
  • Triamcinolone
  • Triamterene
  • Trientine
  • Trihexyphenidyl
  • Trimethoprim
  • Valdecoxib
  • Valsartan

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