Penicillin G Procaine Brand Name– Wycillin
What is Penicillin G Procaine
Penicillin G Procaine is an equimolar compound of procaine and penicillin G antibiotic for intramuscular use.
It provides a tissue depot from which a plateau type of blood level is achieved that lasts over several hours.
Procaine penicillin is indicated for the treatment of moderately severe infections due to penicillin G susceptible organisms that are susceptible to the low and persistent serum levels achieved with this formulation.
Penicillins were initially discovered in 1928 and first used clinically in 1941.
Penicillin G was approved by the FDA in 1943.
Indications
- Actinomyces sp.
- anthrax prophylaxis
- Bacillus anthracis
- bejel
- Clostridium sp.
- Corynebacterium diphtheriae
- diphtheria
- endocarditis
- erysipelas
- Erysipelothrix rhusiopathiae
- Leptospira sp.
- Listeria monocytogenes
- necrotizing ulcerative gingivitis
- Neisseria meningitidis
- neurosyphilis
- pinta
- pneumonia
- rat-bite fever
- scarlet fever
- skin and skin structure infections
- Spirillum minus
- Staphylococcus sp.
- Streptobacillus moniliformis
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- syphilis
- tonsillitis
- Treponema carateum
- Treponema pallidum
- upper respiratory tract infections
- yaws
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anxiety
- arthralgia
- chills
- confusion
- depression
- diarrhea
- edema
- elevated hepatic enzymes
- exfoliative dermatitis
- fever
- hallucinations
- hemolytic anemia
- injection site reaction
- Jarisch-Herxheimer reaction
- leukopenia
- maculopapular rash
- methemoglobinemia
- nausea
- pseudomembranous colitis
- rash
- seizures
- serum sickness
- Stevens-Johnson syndrome
- superinfection
- thrombocytopenia
- tongue discoloration
- toxic epidermal necrolysis
- urticaria
- vomiting
- weakness
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- asthma
- breast-feeding
- carbapenem hypersensitivity
- cardiac disease
- cephalosporin hypersensitivity
- colitis
- diarrhea
- G6PD deficiency
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- intravenous administration
- methemoglobinemia
- neonates
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- pulmonary disease
- renal failure
- renal impairment
- ulcerative colitis
- viral infection
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Aminosalicylate sodium, Aminosalicylic acid
- Amyl Nitrite
- Articaine; Epinephrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Benzocaine
- Benzocaine; Butamben; Tetracaine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Chloroquine
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Colchicine; Probenecid
- Colestipol
- Cyclophosphamide
- Dapsone
- Dichlorphenamide
- Dienogest; Estradiol valerate
- Digoxin
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Erythromycin; Sulfisoxazole
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethacrynic Acid
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Flutamide
- Fosphenytoin
- Furosemide
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydroxyurea
- Ifosfamide
- Indomethacin
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Leflunomide
- Leuprolide; Norethindrone
- Levonorgestrel
- Lidocaine
- Lidocaine; Prilocaine
- Magnesium Salicylate
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Methotrexate
- Metoclopramide
- Nitisinone
- Nitrates
- Nitrofurantoin
- Nitroglycerin
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Phenobarbital
- Phenytoin
- Prilocaine
- Prilocaine; Epinephrine
- Primaquine
- Primidone
- Probenecid
- Pyrimethamine; Sulfadoxine
- Quinine
- Rasburicase
- Ropivacaine
- Salsalate
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Benzoate; Sodium Phenylacetate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Teriflunomide
- Tetracaine
- Tetracyclines
- Typhoid Vaccine
- Valproic Acid, Divalproex Sodium
- Warfarin
