Penicillin G Brand Name– Pfizerpen
What is Penicillin G
Penicillin G (benzylpenicillin) is a naturally derived antibiotic for parenteral use.
It is derived from Penicillium chrysogenum and is commercially available as salts of potassium, sodium, benzathine, and procaine.
The potassium and sodium salts are referred to as the aqueous and crystalline forms of the drug and are administered intravenously or intramuscularly.
Penicillin G is a primary agent for the treatment of Streptococcus pyogenes, S. pneumoniae, and enterococcal infections, although isolates of penicillin-resistant S. pneumoniae are increasing in the US and in many other countries.
Penicillin G is considered the drug of choice for the treatment of treponemal infection.
Benzathine and procaine penicillin are repository forms of penicillin for intramuscular use only; they provide tissue depots from which the drug is absorbed over several hours (e.g., procaine penicillin) or over days (e.g., benzathine penicillin); these specific formulations carry different indications for use and the health care professional should use care in choosing the appropriate product.
Penicillins were initially discovered in 1928 and first used clinically in 1941.
Penicillin G was approved by the FDA in 1943.
Indications
- Actinomyces bovis
- Actinomyces israelii
- Actinomyces sp.
- actinomycosis
- Alcaligenes faecalis
- anthrax
- Bacillus anthracis
- bacteremia
- Borrelia burgdorferi
- botulism
- clostridial diseases
- Clostridium sp.
- community-acquired pneumonia
- Corynebacterium diphtheriae
- diphtheria
- endocarditis
- erysipelas
- Erysipelothrix rhusiopathiae
- Escherichia coli
- Fusobacterium sp.
- gas gangrene
- gonorrhea
- Haemophilus sp.
- infectious arthritis
- Klebsiella aerogenes
- Leptospira sp.
- leptospirosis
- Listeria monocytogenes
- listeriosis
- Lyme disease
- meningitis
- necrotizing ulcerative gingivitis
- Neisseria gonorrhoeae
- Neisseria meningitidis
- neurosyphilis
- optic neuritis
- Pasteurella multocida
- Peptostreptococcus sp.
- pericarditis
- perinatal Group B streptococcal infection prophylaxis
- pleural empyema
- pneumonia
- Prevotella melaninogenica
- Proteus mirabilis
- rat-bite fever
- Salmonella sp.
- Shigella sp.
- skin and skin structure infections
- Spirillum minus
- Staphylococcus sp.
- Streptobacillus moniliformis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus bovis
- Streptococcus dysgalactiae
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp.
- Streptococcus sp. (Group C)
- Streptococcus sp. (Group G)
- Streptococcus sp. (Group H)
- Streptococcus sp. (Group L)
- Streptococcus sp. (Group M)
- syphilis
- tetanus
- Treponema carateum
- Treponema endemicum
- Treponema pallidum
- Treponema pertenue
- uveitis
- Viridans streptococci
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- arthralgia
- azotemia
- bleeding
- bronchospasm
- coma
- diarrhea
- eosinophilia
- exfoliative dermatitis
- fever
- fluid retention
- heart failure
- hematuria
- hemolytic anemia
- hyperkalemia
- hypernatremia
- hyperreflexia
- hypotension
- injection site reaction
- interstitial nephritis
- Jarisch-Herxheimer reaction
- laryngeal edema
- laryngospasm
- maculopapular rash
- malaise
- myalgia
- myoclonia
- nausea
- neutropenia
- phlebitis
- proteinuria
- pruritus
- pseudomembranous colitis
- rash
- renal tubular necrosis
- seizures
- serum sickness
- Stevens-Johnson syndrome
- superinfection
- tongue discoloration
- toxic epidermal necrolysis
- urticaria
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- asthma
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- colitis
- diarrhea
- electrolyte imbalance
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- neonates
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- sexually transmitted disease
- ulcerative colitis
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Colchicine; Probenecid
- Colestipol
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dichlorphenamide
- Dienogest; Estradiol valerate
- Digoxin
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Eplerenone
- Erythromycin; Sulfisoxazole
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethacrynic Acid
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Furosemide
- Guaifenesin; Potassium Guaiacolsulfonate
- Hetastarch; Dextrose; Electrolytes
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Ibritumomab Tiuxetan
- Indomethacin
- Iodine; Potassium Iodide, KI
- Leflunomide
- Leuprolide; Norethindrone
- Levonorgestrel
- Magnesium Salicylate
- Mestranol; Norethindrone
- Methotrexate
- Nitisinone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Potassium
- Potassium Acetate
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Potassium Gluconate
- Potassium Iodide, KI
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Potassium-sparing diuretics
- Probenecid
- Pyrimethamine; Sulfadoxine
- Salsalate
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Benzoate; Sodium Phenylacetate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Spironolactone
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Teriflunomide
- Tetracyclines
- Triamterene
- Typhoid Vaccine
- Warfarin
