Peanut Arachis hypogaea Allergen Powder

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Peanut Arachis hypogaea Allergen Powder Brand Name-Palforzia

What is Peanut Arachis hypogaea Allergen Powder

Peanut Arachis hypogaea Allergen Powder is an oral immunotherapy approved for the mitigation of allergic reactions, including anaphylaxis, due to accidental exposure to peanut in patients 4 years of age and older with a confirmed peanut allergy.

It cannot be used for the emergency treatment of allergic reactions, including anaphylaxis.

Peanut allergy affects approximately 1 million pediatric patients in the United States, and only 1 out of 5 patients will outgrow their allergy. Allergic reactions to peanut are unpredictable; some patients experience severe reactions from even trace amounts.

Physical symptoms can develop within seconds of exposure and may include skin reactions (e.g., hives, redness, or swelling), digestive discomfort, or anaphylaxis.

Antihistamines and epinephrine can be used to treat allergic reactions, but severe reactions can be fatal, even with appropriate and prompt treatment. Treatment with peanut (Arachis hypogaea) allergen powder is administered in 3 sequential phases: Initial Dose Escalation, Up-Dosing, and Maintenance. The Initial Dose Escalation phase is administered in sequential order on a single day.

The Up-Dosing phase consists of 11 increasing dose levels and occurs over several months. Patients that complete all Up-Dosing levels may begin the daily maintenance dose.

Anaphylaxis may occur at any time during peanut (Arachis hypogaea) allergen powder therapy; however, patients are at the highest risk during and after the Initial Dose Escalation and the first dose of each Up-Dosing level.

Therefore, Initial Dose Escalation and the first dose of each Up-Dosing level must be given in a health care provider’s office where the patient can be observed for potential adverse reactions.

If the patient tolerates the first dose of each Up-Dosing level, that dose level may be continued daily at home.

Auto-injectable epinephrine should be available, and patients and caregivers should be properly educated about the signs and symptoms of severe allergic reactions, the proper use of auto-injectable epinephrine, and the need to seek immediate medical attention upon epinephrine use.

Indications

  • peanut allergy

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. cough
  4. dyspnea
  5. nausea
  6. paresthesias
  7. pruritus
  8. rhinorrhea
  9. serious hypersensitivity reactions or anaphylaxis
  10. sneezing
  11. throat irritation
  12. urticaria
  13. vomiting
  14. wheezing

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute bronchospasm
  • angina
  • asthma
  • breast-feeding
  • cardiac arrhythmias
  • chronic lung disease (CLD)
  • chronic obstructive pulmonary disease (COPD)
  • corticosteroid therapy
  • emphysema
  • eosinophilic esophagitis
  • GI disease
  • hypertension
  • myocardial infarction
  • pregnancy
  • requires a specialized care setting
  • requires an experienced clinician
  • serious hypersensitivity reactions or anaphylaxis
  • status asthmaticus

Interactions

There are no drug interactions associated with Peanut Arachis hypogaea Allergen Powder products.

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