Mixed Grass Pollens Allergen Extract

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Mixed Grass Pollens Allergen Extract Brand Name– Oralair

What is Mixed Grass Pollens Allergen Extract

Mixed grass pollens allergen extract is an oral immunotherapy approved for treatment of allergic rhinitis (hay fever) with or without conjunctivitis that is induced by certain grass pollens in people ages 5 to 65 years.

Mixed grass pollens allergen extract contains a mixture of freeze-dried extracts from the pollens of 5 grass species, including Kentucky Blue Grass, Orchard, Perennial Rye, Sweet Vernal, and Timothy.

Severe allergic reactions, such as anaphylaxis, which can be life-threatening, can occur.

After administration of the first dose at the health care provider’s office, where the patient can be observed for potential adverse reactions, mixed grass pollens allergen extract can be taken at home

Indications

  • allergic conjunctivitis
  • allergic rhinitis
  • Hypersensitivity to at least 1 of the 5 grass pollens contained in the product (Sweet Vernal, Orchard, Perennial Rye, Timothy, or Kentucky Bluegrass) should be confirmed by positive skin test or in vitro testing for pollen-specific IgE antibodies prior to administration.
  • Initiate treatment 4 months prior to the expected onset of each grass pollen season and continue throughout the season.
  • Safety data regarding starting treatment during the grass pollen season or restarting treatment after missing a dose are not available.

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. angioedema
  5. anxiety
  6. asthenia
  7. atopic dermatitis
  8. chest pain (unspecified)
  9. cough
  10. diarrhea
  11. dizziness
  12. drowsiness
  13. dyspepsia
  14. dysphagia
  15. dysphonia
  16. dyspnea
  17. edema
  18. eosinophilia
  19. esophagitis
  20. flushing
  21. gastritis
  22. gastroesophageal reflux
  23. headache
  24. hyperemia
  25. hypersalivation
  26. hypoesthesia
  27. hypotension
  28. infection
  29. laryngeal edema
  30. lymphadenopathy
  31. malaise
  32. myocarditis
  33. nausea
  34. pallor
  35. palpitations
  36. paresthesias
  37. pruritus
  38. rash
  39. serious hypersensitivity reactions or anaphylaxis
  40. sinus tachycardia
  41. stomatitis
  42. throat irritation
  43. tinnitus
  44. urticaria
  45. vomiting
  46. weight loss
  47. wheezing
  48. xerophthalmia
  49. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute bronchospasm
  • angina
  • asthma
  • atopy
  • breast-feeding
  • cardiac arrhythmias
  • chronic lung disease (CLD)
  • chronic obstructive pulmonary disease (COPD)
  • dental work
  • emphysema
  • eosinophilic esophagitis
  • hypertension
  • inflammation
  • mannitol hypersensitivity
  • myocardial infarction
  • pregnancy
  • requires a specialized care setting
  • serious hypersensitivity reactions or anaphylaxis
  • status asthmaticus
  • sublingual allergen immunotherapy hypersensitivity

Interactions

There are no drug interactions associated with Mixed Grass Pollens Allergen Extract products.

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