House Dust Mite Allergen Extract

House Dust Mite Allergen Extract Brand Name– ODACTRA 12

What is House Dust Mite Allergen Extract (HDM allergen extract)

House dust mite allergen extract is a sublingual immunotherapy (SLIT) approved for the treatment of allergic rhinitis with or without conjunctivitis in adults 18 through 65 years of age.

HDM allergy is confirmed by in vitro testing for IgE antibodies to Dermatophagoides farinae or Dermatophagoides pteronyssinus house dust mites, or skin testing to licensed house dust mite allergen extracts.

Allergen immunotherapy modifies the disease process and is used in patients who are not adequately controlled with environmental or medication changes.

In general, SLIT is associated with fewer serious adverse reactions than subcutaneous immunotherapy; however, experience with SLIT in patients with severe asthma, a population that may be more likely to experience serious reactions, is limited. Most adverse reactions to SLIT are local and transient and do not require treatment discontinuation.

However, as with any immunotherapy, severe systemic and local allergic reactions (e.g., anaphylaxis, laryngopharyngeal swelling) are possible.

After administration of the first dose at the health care provider’s office, where the patient can be observed for potential adverse reactions,

HDM allergen extract can be taken at home.

HDM allergen extract was approved by the FDA in March 2017.

Indications

  • allergic conjunctivitis
  • allergic rhinitis
  • Prior to use: Hypersensitivity to house dust mite (HDM) allergen should be confirmed by in vitro testing for IgE antibodies to Dermatophagoides farinae or Dermatophagoides pteronyssinus house dust mites, or skin testing to licensed house dust mite allergen extracts.

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. angioedema
  5. chest pain (unspecified)
  6. diarrhea
  7. dysgeusia
  8. dyspepsia
  9. dysphagia
  10. erythema
  11. esophagitis
  12. fatigue
  13. gastroesophageal reflux
  14. hypoesthesia
  15. infection
  16. nausea
  17. ocular pruritus
  18. oral ulceration
  19. paresthesias
  20. pruritus
  21. serious hypersensitivity reactions or anaphylaxis
  22. sneezing
  23. stomatitis
  24. throat irritation
  25. urticaria
  26. vomiting

Contraindications

  • acute bronchospasm
  • angina
  • asthma
  • atopy
  • breast-feeding
  • cardiac arrhythmias
  • children
  • chronic lung disease (CLD)
  • chronic obstructive pulmonary disease (COPD)
  • dental work
  • emphysema
  • eosinophilic esophagitis
  • fish hypersensitivity
  • gelatin hypersensitivity
  • geriatric
  • hypertension
  • infants
  • inflammation
  • mannitol hypersensitivity
  • myocardial infarction
  • pregnancy
  • pulmonary disease
  • requires a specialized care setting
  • serious hypersensitivity reactions or anaphylaxis
  • status asthmaticus
  • stomatitis
  • sublingual allergen immunotherapy hypersensitivity

Interactions

There are no drug interactions associated with House Dust Mite Allergen Extract products.

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