Nanoparticle Albumin Bound Paclitaxel

Nanoparticle Albumin Bound Paclitaxel Brand Name– Abraxane

What is Nanoparticle Albumin Bound Paclitaxel

Nanoparticle albumin bound paclitaxel is a microtubule inhibitor that works by assembling and stabilizing microtubules which prevents depolymerization and cell division during mitosis.

It is indicated as a single-agent for the treatment of metastatic breast cancer (mBC), in combination with carboplatin for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC), and in combination with gemcitabine for the treatment of metastatic adenocarcinoma of the pancreas.

The nab-paclitaxel formulation uses nanotechnology to combine human albumin with paclitaxel allowing for the delivery of an insoluble drug in the form of nanoparticles (less than 200 nanometers in diameter).

This formulation increases the bioavailability of paclitaxel and results in higher intratumor concentrations.

Nab-paclitaxel targets tumors and tumor penetration is facilitated by albumin-receptor (gp60) mediated endothelial transcytosis.

This formulation does not require the solvent, Cremophor; therefore, no premedication or special tubing are required with nab-paclitaxel use.

Severe neutropenia has been reported and may necessitate an interruption of therapy or dose reduction; new cycles of nab-paclitaxel should not begin until the ANC is 1,500 cells/mm³ or more

Indications

1. breast cancer
2. non-small cell lung cancer (NSCLC)
3. pancreatic cancer

For the treatment of breast cancer

for the treatment of previously untreated metastatic breast cancer

Side Effects

1. alopecia
2. alopecia
3. anaphylactoid reactions
4. anemia
5. anemia
6. anorexia
7. anorexia
8. arthralgia
9. arthralgia
10. asthenia
11. asthenia
12. bleeding
13. blurred vision
14. bone marrow suppression
15. bradycardia
16. candidiasis
17. cardiac arrest
18. chest pain (unspecified)
19. colitis
20. conjunctivitis
21. constipation
22. cough
23. cranial nerve palsies
24. cystitis
25. cystitis
26. dehydration
27. dehydration
28. depression
29. depression
30. diarrhea
31. diarrhea
32. dysgeusia
33. dyspnea
34. edema
35. elevated hepatic enzymes
36. epistaxis
37. erythema
38. fatigue
39. fatigue
40. fever
41. fever
42. GI obstruction
43. GI perforation
44. headache
45. headache
46. heart failure
47. hepatic encephalopathy
48. hepatic necrosis
49. hyperbilirubinemia
50. hypertension
51. hypokalemia
52. hypokalemia
53. hypotension
54. ileus
55. infection
56. injection site reaction
57. keratitis
58. lacrimation
59. macular edema
60. maculopapular rash
61. myalgia
62. myalgia
63. nail discoloration
64. nausea
65. nausea
66. neutropenia
67. neutropenia
68. palmar-plantar erythrodysesthesia (hand and foot syndrome)
69. pancreatitis
70. pancytopenia
71. paresis
72. peripheral edema
73. peripheral edema
74. peripheral neuropathy
75. peripheral neuropathy
76. phlebitis
77. photosensitivity
78. pneumonitis
79. pneumothorax
80. pruritus
81. pulmonary embolism
82. pulmonary fibrosis
83. radiation recall reaction
84. rash
85. rash
86. renal failure (unspecified)
87. sinus tachycardia
88. Stevens-Johnson syndrome
89. stomatitis
90. stomatitis
91. stroke
92. supraventricular tachycardia (SVT)
93. thrombocytopenia
94. thrombocytopenia
95. thromboembolism
96. thrombosis
97. toxic epidermal necrolysis
98. tumor lysis syndrome (TLS)
99. typhlitis
100. visual impairment
101. visual impairment
102. vomiting
103. vomiting

Monitoring Parameters

• CBC with differential
• LFTs
• pregnancy testing

Contraindications

• albumin hypersensitivity
• biliary obstruction
• bone marrow suppression
• breast-feeding
• chronic lung disease (CLD)
• contraception requirements
• ensure correct formulation selection
• extravasation
• fever
• geriatric
• hepatic disease
• infertility
• male-mediated teratogenicity
• neutropenia
• peripheral neuropathy
• pneumonitis
• pregnancy
• pregnancy testing
• pulmonary disease
• reproductive risk
• sepsis
• taxane hypersensitivity
• thrombocytopenia
• viral infection

Interactions

• Abiraterone
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Amiodarone
• Amobarbital
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Apalutamide
• Aprepitant, Fosaprepitant
• Armodafinil
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Atazanavir
• Atazanavir; Cobicistat
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Bexarotene
• Bosentan
• Brigatinib
• Butabarbital
• Cannabidiol
• Carbamazepine
• Cenobamate
• Ceritinib
• Chloramphenicol
• Ciprofloxacin
• Clarithromycin
• Clobazam
• Clopidogrel
• Cobicistat
• Conivaptan
• Crizotinib
• Cyclosporine
• Dabrafenib
• Danazol
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Deferasirox
• Delavirdine
• Dexamethasone
• Diltiazem
• Dronedarone
• Duvelisib
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix
• Elagolix; Estradiol; Norethindrone acetate
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Enzalutamide
• Erlotinib
• Erythromycin
• Erythromycin; Sulfisoxazole
• Eslicarbazepine
• Etravirine
• Fedratinib
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Fosamprenavir
• Fosphenytoin
• Gemfibrozil
• grapefruit juice
• Idelalisib
• Imatinib
• Indinavir
• Isavuconazonium
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Itraconazole
• Ketoconazole
• Lapatinib
• Lefamulin
• Leflunomide
• Lesinurad
• Lesinurad; Allopurinol
• Letermovir
• Lopinavir; Ritonavir
• Lorlatinib
• Lumacaftor; Ivacaftor
• Lumacaftor; Ivacaftor
• Mephobarbital
• Methohexital
• Mifepristone
• Mitotane
• Modafinil
• Nafcillin
• Nefazodone
• Nelfinavir
• Netupitant, Fosnetupitant; Palonosetron
• Nevirapine
• Nicardipine
• Nilotinib
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Oritavancin
• Oxcarbazepine
• Palifermin
• Penicillamine
• Pentobarbital
• Phenobarbital
• Phenytoin
• Posaconazole
• Primidone
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifapentine
• Rifaximin
• Ritonavir
• Saquinavir
• Secobarbital
• Selpercatinib
• St. John’s Wort, Hypericum perforatum
• Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
• Tazemetostat
• Telithromycin
• Telotristat Ethyl
• Teriflunomide
• Thiopental
• Tipranavir
• Trandolapril; Verapamil
• Trimethoprim
• Tuberculin Purified Protein Derivative, PPD
• Tucatinib
• Verapamil
• Voriconazole
• Zanubrutinib