Nandrolone Decanoate

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Nandrolone Decanoate Brand Name– Deca-Durabolin

What is Nandrolone Decanoate

Nandrolone decanoate is a parenteral anabolic steroid. It is used to manage the anemia of chronic renal failure and for osteoporosis.

This agent will increase hemoglobin and red cell mass. With the development of recombinant human erythropoietin, nandrolone decanoate use in anemia associated with chronic renal failure has declined.

Data on the effects of combining nandrolone decanoate and epoetin alfa are lacking. Anabolic steroids also promote body tissue-building processes and reverse catabolic or tissue-depleting processes.

They have also been the subject of drug misuse and abuse, often producing adverse effects such as changes in libido, hepatotoxicity, increased risk of cardiovascular disease, and antisocial behavior.

Some of the masculinizing effects in women can be irreversible. When using androgens and anabolic steroids, it is important to provide adequate calorie and protein intake to maintain a positive nitrogen balance.

Nandrolone decanoate was approved by the FDA in 1983 and became a controlled substance in 1991.

Indications

  1. AIDS-associated wasting syndrome
  2. anemia
  3. cachexia
  4. osteoporosis

For the treatment of anemia associated with chronic renal failure

Side Effects

  1. acne vulgaris
  2. acneiform rash
  3. alopecia
  4. amenorrhea
  5. clitoromegaly
  6. decreased ejaculate volume
  7. depression
  8. diarrhea
  9. elevated hepatic enzymes
  10. epididymitis
  11. epiphyseal closure
  12. excitability
  13. feminization
  14. fluid retention
  15. gynecomastia
  16. hepatic failure
  17. hepatic necrosis
  18. hepatitis
  19. hirsutism
  20. hoarseness
  21. hypercalcemia
  22. hypercholesterolemia
  23. impotence (erectile dysfunction)
  24. injection site reaction
  25. insomnia
  26. jaundice
  27. libido decrease
  28. libido increase
  29. mastalgia
  30. menstrual irregularity
  31. nausea
  32. new primary malignancy
  33. oligomenorrhea
  34. oligospermia
  35. peliosis hepatis
  36. penile enlargement
  37. peripheral edema
  38. priapism
  39. prolonged bleeding time
  40. prostatic hypertrophy
  41. sodium retention
  42. teratogenesis
  43. testicular atrophy
  44. tumorigenicity
  45. virilization
  46. vomiting
  47. weight gain

Monitoring Parameters

  • LFTs

Contraindications

  • arteriosclerosis
  • benzyl alcohol hypersensitivity
  • breast cancer
  • breast-feeding
  • cardiac disease
  • children
  • cholestasis
  • coronary artery disease
  • diabetes mellitus
  • heart failure
  • hepatic disease
  • hypercalcemia
  • hypercholesterolemia
  • intravenous administration
  • jaundice
  • myocardial infarction
  • new primary malignancy
  • peliosis hepatis
  • peripheral edema
  • pregnancy
  • prostate cancer
  • prostatic hypertrophy
  • renal disease
  • tumorigenicity

Interactions

  • Abarelix
  • Acarbose
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Anticoagulants
  • Canagliflozin
  • Canagliflozin; Metformin
  • Cyclosporine
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darbepoetin Alfa
  • Degarelix
  • Dipeptidyl Peptidase-4 Inhibitors
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Epoetin Alfa
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Goserelin
  • Histrelin
  • Incretin Mimetics
  • Insulins
  • Leuprolide
  • Leuprolide; Norethindrone
  • Linagliptin
  • Linagliptin; Metformin
  • Meglitinides
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methoxy polyethylene glycol-epoetin beta
  • Miglitol
  • Nafarelin
  • Pramlintide
  • Saw Palmetto, Serenoa repens
  • Saxagliptin
  • SGLT2 Inhibitors
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sulfonylureas
  • Thiazolidinediones
  • Triptorelin

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