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Naftifine Brand Names- Naftin | Naftin-MP

What is Naftifine

Naftifine is a topical antifungal agent for interdigital tinea pedis, tinea cruris, and tinea corporis; limited efficacy has been shown for the treatment of onychomycosis.

It is the first of the allylamine class of antifungals. Unlike the azoles, the allylamines exhibit fungicidal activity at low doses and have the potential for a faster onset of action. In general, however, efficacy and adverse event profiles are similar to the topical azoles.

Naftifine is available as a 1% and 2% cream, and a 1% and 2% gel. The 1% gel and the cream formulations are approved for treatment of tinea pedis, tinea cruris, and tinea corporis; the 2% gel is only approved for treatment of interdigital tinea pedis.

The antifungal spectrum of activity includes: Trichophyton rubrum (all formulations), Trichophyton mentagrophytes (1% cream, 1% and 2% gel), Epidermophyton floccosum (1% cream, 1% and 2% gel), and Trichophyton tonsurans (1% gel). 

The cream has been shown to be equivalent in efficacy to clotrimazole 1% cream, miconazole 1% cream, econazole 1% cream, tolnaftate, and topical terbinafine in the treatment of dermatophytes.

Naftifine was approved by the FDA in 1988.


  1. Aspergillus flavus
  2. Aspergillus fumigatus
  3. Candida albicans
  4. Candida sp.
  5. Epidermophyton floccosum
  6. Microsporum audouinii
  7. Microsporum canis
  8. Microsporum gypseum
  9. onychomycosis
  10. Sporothrix schenckii
  11. tinea corporis
  12. tinea cruris
  13. tinea pedis
  14. Trichophyton mentagrophytes
  15. Trichophyton rubrum
  16. Trichophyton tonsurans
  17. Trichophyton verrucosum

Side Effects

  1. agranulocytosis
  2. contact dermatitis
  3. dizziness
  4. erythema
  5. headache
  6. leukopenia
  7. pruritus
  8. rash
  9. skin irritation

Monitoring Parameters

  • laboratory monitoring not necessary


  • accidental exposure
  • breast-feeding
  • children
  • infants
  • neonates
  • occlusive dressing
  • ocular exposure
  • pregnancy


There are no drug interactions associated with Naftifine products.

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