Nafcillin

Nafcillin Brand Name– Nallpen

What is Nafcillin

Nafcillin is a semisynthetic antistaphylococcal penicillin. Unlike penicillin, ampicillin, or the extended-spectrum penicillins, nafcillin resists hydrolysis by penicillinase.

As a result, nafcillin, along with other agents in the same group (e.g., oxacillin, dicloxacillin), is active against penicillinase-producing S.aureus.

The risk of interstitial nephritis is less with nafcillin than with methicillin; however, dicloxacillin is preferred over nafcillin when oral therapy is desired due to more reliable gastrointestinal absorption.

Clinical uses of nafcillin include bacteremia, skin and soft-tissue infections, respiratory tract infections, bone and joint infections, and urinary tract infections.

Nafcillin was approved by the FDA in 1964.

Indications

  1. bacteremia
  2. bone and joint infections
  3. cellulitis
  4. community-acquired pneumonia
  5. endocarditis
  6. infectious arthritis
  7. lower respiratory tract infections
  8. mastitis
  9. meningitis
  10. neonatal mastitis
  11. osteomyelitis
  12. pneumonia
  13. skin and skin structure infections
  14. Staphylococcus aureus (MSSA)
  15. Staphylococcus sp.

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. angioedema
  6. arthralgia
  7. bronchospasm
  8. cholestasis
  9. diarrhea
  10. elevated hepatic enzymes
  11. eosinophilia
  12. exfoliative dermatitis
  13. fever
  14. hematuria
  15. hypotension
  16. injection site reaction
  17. interstitial nephritis
  18. laryngeal edema
  19. laryngospasm
  20. malaise
  21. myalgia
  22. nausea
  23. neutropenia
  24. phlebitis
  25. proteinuria
  26. pruritus
  27. pseudomembranous colitis
  28. rash
  29. renal tubular necrosis
  30. seizures
  31. serum sickness
  32. Stevens-Johnson syndrome
  33. stomatitis
  34. superinfection
  35. tissue necrosis
  36. tongue discoloration
  37. toxic epidermal necrolysis
  38. urticaria
  39. vomiting

Hematologic adverse effects such as agranulocytosis, neutropenia, and bone marrow depression have occurred during nafcillin therapy.

Monitoring Parameters

  • CBC
  • LFTs
  • serum alkaline phosphatase
  • serum bilirubin
  • serum creatinine/BUN
  • urinalysis

Contraindications

  • asthma
  • breast-feeding
  • carbapenem hypersensitivity
  • cephalosporin hypersensitivity
  • colitis
  • diarrhea
  • eczema
  • electrolyte imbalance
  • extravasation
  • geriatric
  • GI disease
  • heart failure
  • hepatic disease
  • inflammatory bowel disease
  • jaundice
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • ulcerative colitis

Interactions

  • Abemaciclib
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Aprepitant, Fosaprepitant
  • Artemether; Lumefantrine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Avapritinib
  • Axitinib
  • Bedaquiline
  • Benzhydrocodone; Acetaminophen
  • Boceprevir
  • Brigatinib
  • Bromocriptine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Capmatinib
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Choline Salicylate; Magnesium Salicylate
  • Cobicistat
  • Cobimetinib
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine; Probenecid
  • Cyclophosphamide
  • Cyclosporine
  • Daclatasvir
  • Dapsone
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deflazacort
  • Dichlorphenamide
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dolutegravir; Rilpivirine
  • Doravirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Elbasvir; Grazoprevir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Encorafenib
  • Entrectinib
  • Erdafitinib
  • Erlotinib
  • Ethacrynic Acid
  • Fedratinib
  • Fentanyl
  • Flibanserin
  • food
  • Furosemide
  • Glasdegib
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibrutinib
  • Ibuprofen; Oxycodone
  • Ifosfamide
  • Indomethacin
  • Isavuconazonium
  • Ixabepilone
  • Lefamulin
  • Lemborexant
  • Letermovir
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorlatinib
  • Lumateperone
  • Lurbinectedin
  • Magnesium Salicylate
  • Maraviroc
  • Methotrexate
  • Nanoparticle Albumin-Bound Paclitaxel
  • Neratinib
  • Nisoldipine
  • Olaparib
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oral Contraceptives
  • Oxycodone
  • Pazopanib
  • Pemigatinib
  • Perampanel
  • Perindopril; Amlodipine
  • Pimavanserin
  • Praziquantel
  • Probenecid
  • Rilpivirine
  • Rimegepant
  • Ritonavir
  • Rivaroxaban
  • Romidepsin
  • Ruxolitinib
  • Salsalate
  • Selpercatinib
  • Selumetinib
  • Siponimod
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Sonidegib
  • Sufentanil
  • Sunitinib
  • Tazemetostat
  • Telaprevir
  • Terbinafine
  • Tetracyclines
  • Tolvaptan
  • Typhoid Vaccine
  • Ubrogepant
  • Venetoclax
  • Vincristine
  • Vincristine Liposomal
  • Vorapaxar
  • Voxelotor
  • Warfarin
  • Zanubrutinib
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856