Ciclopirox Brand Names

Ciclodan | Loprox | Loprox TS | Penlac

What is Ciclopirox

Ciclopirox olamine is a topical antifungal agent which has antifungal activity similar to the imidazoles.

The 1% cream and lotion formulations are well-tolerated and have similar efficacy compared to clotrimazole. They are used primarily for the treatment of tinea pedis, tinea cruris, tinea corporis (ring worm), and tinea versicolor.

Loprox® 1% cream was approved by the FDA in 1982, and subsequently the 1% lotion was introduced in 1988; the concentrations of these formulations were later reduced to 0.77%.

The lotion was discontinued in January 2003. The new formulation, Loprox® TS, is a hybrid of the cream and lotion formulations to give a thicker texture; it is considered therapeutically equivalent to the lotion.

Penlac™ Nail Lacquer (Ciclopirox) Topical Solution (8%) was approved by the FDA on December 17th, 1999 for the topical treatment of mild to moderate onychomycosis of the fingernails or toenails without lunula involvement in immunocompetent patients.

A 1% shampoo was approved February 28, 2003 for treatment of seborrheic dermatitis of the scalp.


  1. Candida albicans
  2. candidiasis
  3. Epidermophyton floccosum
  4. Malassezia furfur
  5. Microsporum canis
  6. onychomycosis
  7. seborrheic dermatitis
  8. tinea corporis
  9. tinea cruris
  10. tinea pedis
  11. tinea versicolor
  12. Trichophyton mentagrophytes
  13. Trichophyton rubrum

Side Effects

  1. acneiform rash
  2. alopecia
  3. contact dermatitis
  4. erythema
  5. hair discoloration
  6. headache
  7. nail discoloration
  8. pruritus
  9. rash
  10. ventricular tachycardia
  11. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary


  • breast-feeding
  • children
  • corticosteroid therapy
  • diabetes mellitus
  • geriatric
  • human immunodeficiency virus (HIV) infection
  • immunosuppression
  • infants
  • neonates
  • ocular exposure
  • onychomycosis
  • organ transplant
  • peripheral vascular disease
  • pregnancy
  • seizure disorder
  • skin abrasion


There are no drug interactions associated with Ciclopirox products.


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