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Ciclopirox Brand Names
Ciclodan | Loprox | Loprox TS | Penlac
What is Ciclopirox
Ciclopirox olamine is a topical antifungal agent which has antifungal activity similar to the imidazoles.
The 1% cream and lotion formulations are well-tolerated and have similar efficacy compared to clotrimazole. They are used primarily for the treatment of tinea pedis, tinea cruris, tinea corporis (ring worm), and tinea versicolor.
Loprox® 1% cream was approved by the FDA in 1982, and subsequently the 1% lotion was introduced in 1988; the concentrations of these formulations were later reduced to 0.77%.
The lotion was discontinued in January 2003. The new formulation, Loprox® TS, is a hybrid of the cream and lotion formulations to give a thicker texture; it is considered therapeutically equivalent to the lotion.
Penlac™ Nail Lacquer (Ciclopirox) Topical Solution (8%) was approved by the FDA on December 17th, 1999 for the topical treatment of mild to moderate onychomycosis of the fingernails or toenails without lunula involvement in immunocompetent patients.
A 1% shampoo was approved February 28, 2003 for treatment of seborrheic dermatitis of the scalp.
Indications
- Candida albicans
- candidiasis
- Epidermophyton floccosum
- Malassezia furfur
- Microsporum canis
- onychomycosis
- seborrheic dermatitis
- tinea corporis
- tinea cruris
- tinea pedis
- tinea versicolor
- Trichophyton mentagrophytes
- Trichophyton rubrum
Side Effects
- acneiform rash
- alopecia
- contact dermatitis
- erythema
- hair discoloration
- headache
- nail discoloration
- pruritus
- rash
- ventricular tachycardia
- xerosis
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- children
- corticosteroid therapy
- diabetes mellitus
- geriatric
- human immunodeficiency virus (HIV) infection
- immunosuppression
- infants
- neonates
- ocular exposure
- onychomycosis
- organ transplant
- peripheral vascular disease
- pregnancy
- seizure disorder
- skin abrasion
Interactions
There are no drug interactions associated with Ciclopirox products.
