Mometasone

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Mometasone Brand Names

Asmanex | Asmanex HFA | Elocon | Nasonex | Propel | Propel Contour | SINUVA

What is Mometasone

Mometasone is a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties; products are available in topical, nasal, and inhaled dosage forms.

Mometasone is used topically to relieve the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and psoriasis. Most mometasone products are of medium-potency; however, the mometasone ointment is considered more potent.

Topical mometasone is resistant to metabolism in the skin, and repeated applications may lead to a depot effect and prolonged actions and an increased risk of systemic absorption.

Nasal topical sprays treat symptoms of perennial or seasonal allergic rhinitis, and sinus implants containing mometasone are used to reduce inflammation and the recurrence of nasal polyps following sinus surgery. Respiratory inhalations are used for the maintenance treatment of asthma.

For the treatment of asthma, the dry powder formulation has the advantage in that it can be given once daily, as opposed to the other ICSs that must be given twice daily.

Inhaled corticosteroids (ICSs) are the preferred pharmacologic treatment in the long-term management of asthma.

Maintenance ICS therapy may also decrease the frequency and severity of exercise-induced bronchoconstriction (EIB); short-acting beta-2 agonists (SABAs) also help prevent EIB but tolerance can develop with regular SABA use

Indications

  1. allergic rhinitis
  2. allergic rhinitis prophylaxis
  3. alopecia
  4. asthma
  5. atopic dermatitis
  6. contact dermatitis
  7. discoid lupus erythematosus
  8. eczema
  9. exercise-induced bronchospasm prophylaxis
  10. exfoliative dermatitis
  11. granuloma annulare
  12. keloids
  13. lichen planus
  14. lichen striatus
  15. nasal congestion
  16. nasal polyps
  17. necrobiosis lipoidica diabeticorum
  18. pemphigus
  19. perennial allergies
  20. pityriasis rosea
  21. polymorphous light eruption
  22. pruritus
  23. psoriasis
  24. Rhus dermatitis
  25. sarcoidosis
  26. seasonal allergies
  27. seborrheic dermatitis
  28. sinus patency maintenance
  29. sinusitis
  30. xerosis

Side Effects

  1. abdominal pain
  2. acneiform rash
  3. adrenocortical insufficiency
  4. anaphylactoid reactions
  5. angioedema
  6. anorexia
  7. arthralgia
  8. back pain
  9. blurred vision
  10. bronchospasm
  11. candidiasis
  12. cataracts
  13. chest pain (unspecified)
  14. conjunctivitis
  15. contact dermatitis
  16. cough
  17. Cushing’s syndrome
  18. depression
  19. diarrhea
  20. dysgeusia
  21. dysmenorrhea
  22. dyspepsia
  23. dysphonia
  24. dyspnea
  25. epistaxis
  26. erythema
  27. fatigue
  28. fever
  29. folliculitis
  30. foreign body sensation
  31. furunculosis
  32. glycosuria
  33. growth inhibition
  34. headache
  35. hyperesthesia
  36. hyperglycemia
  37. hypertrichosis
  38. hypothalamic-pituitary-adrenal (HPA) suppression
  39. immunosuppression
  40. impaired wound healing
  41. increased intracranial pressure
  42. infection
  43. miliaria
  44. musculoskeletal pain
  45. myalgia
  46. nasal congestion
  47. nasal dryness
  48. nasal irritation
  49. nasal septum perforation
  50. nausea
  51. ocular hypertension
  52. osteopenia
  53. osteoporosis
  54. otalgia
  55. papilledema
  56. paresthesias
  57. parosmia
  58. pharyngitis
  59. pruritus
  60. purpura
  61. rash
  62. retinopathy
  63. rhinitis
  64. sinusitis
  65. skin atrophy
  66. skin hypopigmentation
  67. skin irritation
  68. skin ulcer
  69. striae
  70. telangiectasia
  71. throat irritation
  72. toxic-shock syndrome
  73. visual impairment
  74. vomiting
  75. wheezing
  76. withdrawal
  77. xerosis
  78. xerostomia

Monitoring Parameters

  • pulmonary function tests (PFTs)

Contraindications

  • abrupt discontinuation
  • acne rosacea
  • acne vulgaris
  • acute bronchospasm
  • adrenal insufficiency
  • breast-feeding
  • cataracts
  • children
  • corticosteroid hypersensitivity
  • Cushing’s syndrome
  • diabetes mellitus
  • fungal infection
  • geriatric
  • glaucoma
  • growth inhibition
  • hepatic disease
  • herpes infection
  • hyperglycemia
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • increased intracranial pressure
  • increased intraocular pressure
  • infants
  • infection
  • measles
  • milk protein hypersensitivity
  • nasal septal perforation
  • nasal surgery
  • nasal trauma
  • neonates
  • occlusive dressing
  • ocular exposure
  • osteoporosis
  • paradoxical bronchospasm
  • perioral dermatitis
  • peripheral vascular disease
  • pregnancy
  • skin abrasion
  • skin atrophy
  • status asthmaticus
  • sunlight (UV) exposure
  • surgery
  • tuberculosis
  • varicella
  • viral infection
  • visual disturbance

Interactions

  • Abatacept
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetazolamide
  • Acetohexamide
  • Adalimumab
  • Albiglutide
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Metformin
  • Alpha-glucosidase Inhibitors
  • Altretamine
  • Ambenonium Chloride
  • Amifampridine
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminolevulinic Acid
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Argatroban
  • Arsenic Trioxide
  • Asparaginase Erwinia chrysanthemi
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol; Chlorthalidone
  • Atracurium
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Azathioprine
  • Azilsartan; Chlorthalidone
  • Basiliximab
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bepridil
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bivalirudin
  • Boceprevir
  • Bortezomib
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Bupropion
  • Bupropion; Naltrexone
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Phenylephrine
  • Carmustine, BCNU
  • Ceritinib
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorambucil
  • Chloramphenicol
  • Chlorothiazide
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Choline Salicylate; Magnesium Salicylate
  • Cimetidine
  • Cisatracurium
  • Citalopram
  • Clarithromycin
  • Clindamycin
  • Clofarabine
  • Cobicistat
  • Codeine; Phenylephrine; Promethazine
  • Conivaptan
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Denileukin Diftitox
  • Denosumab
  • Desmopressin
  • Dextran
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Digoxin
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dofetilide
  • Doxacurium
  • Droperidol
  • Dulaglutide
  • Echinacea
  • Econazole
  • Efalizumab
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Estramustine
  • Estrogens
  • Exenatide
  • Fluconazole
  • Fluoxymesterone
  • Fosamprenavir
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gallium Ga 68 Dotatate
  • Gemcitabine
  • Gentamicin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycerol Phenylbutyrate
  • grapefruit juice
  • Guaifenesin; Phenylephrine
  • Halofantrine
  • Haloperidol
  • Hemin
  • Heparin
  • Hetastarch
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Hydroxyurea
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Idelalisib
  • Incretin Mimetics
  • Indapamide
  • Indinavir
  • Inebilizumab
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Isoproterenol
  • Isotretinoin
  • Itraconazole
  • Ketoconazole
  • L-Asparaginase Escherichia coli
  • Levetiracetam
  • Levomethadyl
  • Linagliptin; Metformin
  • Liraglutide
  • Lixisenatide
  • Lomustine, CCNU
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Macimorelin
  • Magnesium Salicylate
  • Mannitol
  • Mecasermin rinfabate
  • Mecasermin, Recombinant, rh-IGF-1
  • Meglitinides
  • Melphalan
  • Mepenzolate
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methacholine
  • Methazolamide
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methoxsalen
  • Methyclothiazide
  • Metolazone
  • Metyrapone
  • Micafungin
  • Mifepristone
  • Mitoxantrone
  • Mivacurium
  • Moxifloxacin
  • Muromonab-CD3
  • Natalizumab
  • Nateglinide
  • Nefazodone
  • Nelarabine
  • Nelfinavir
  • Neostigmine
  • Neuromuscular blockers
  • Nicardipine
  • Nonsteroidal antiinflammatory drugs
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ondansetron
  • Oxymetholone
  • Pancuronium
  • Pegaspargase
  • Penicillamine
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Photosensitizing agents (topical)
  • Physostigmine
  • Pimozide
  • Posaconazole
  • Potassium
  • Potassium Chloride
  • Potassium Phosphate; Sodium Phosphate
  • Potassium-sparing diuretics
  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Propranolol
  • Purine analogs
  • Pyridostigmine
  • Quetiapine
  • Rapacuronium
  • Regular Insulin
  • Repaglinide
  • Ribociclib
  • Ribociclib; Letrozole
  • Ritodrine
  • Ritonavir
  • Rituximab
  • Rituximab; Hyaluronidase
  • Rocuronium
  • Salicylates
  • Salsalate
  • Saquinavir
  • Sargramostim, GM-CSF
  • Semaglutide
  • SGLT2 Inhibitors
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium Chloride
  • Sodium Phenylbutyrate
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Somatropin, rh-GH
  • Succinylcholine
  • Sulfonylureas
  • Telaprevir
  • Telbivudine
  • Telithromycin
  • Testosterone
  • Thiazide diuretics
  • Thiazolidinediones
  • Thyroid hormones
  • Tipranavir
  • Tobramycin
  • Tolazamide
  • Tolbutamide
  • Tositumomab
  • Tranexamic Acid
  • Tretinoin, ATRA
  • Tuberculin Purified Protein Derivative, PPD
  • Tubocurarine
  • Tucatinib
  • Vancomycin
  • Vecuronium
  • Vigabatrin
  • Vincristine Liposomal
  • Vorinostat
  • Warfarin
  • Zafirlukast

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